Title:Quality of Life in Patients with β-thalassemia Major: Short-term and Long-term Effects After Haematopoietic Stem Cell Transplantation
Volume: 16
Issue: 8
Author(s): Lu Zhai, Yuhua Liu, Rongrui Huo, Zhaofang Pan, Juan Bin, Zhi Li, Qiaomei Tang and Jing Fan*
Affiliation:
- Department of Stem Cell Transplantation, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi,China
Keywords:
Quality of life, β-thalassemia major, haematopoietic stem cell transplantation, blood infusion, iron-chelating therapy,
bone marrow.
Abstract:
Background: Allogeneic haematopoietic stem cell transplantation (ALLO-HSCT) is a
potentially curative approach to treat β-thalassemia major (β-TM).
Objective and Methods: To assess the quality of life (QOL) of patients with β-TM after ALLO-HSCT,
we searched PubMed, Embase, Web of Science, and MEDLINE for articles on the quality of
life (QOL) of patients with β-TM from 1 Feb 2020 to 31 Mar 2020.
Results: Our review revealed that the QOL of patients with β-TM after ALLO-HSCT from a sibling
donor is higher than that of patients that received blood infusion and iron-chelating therapy.
Survivors of ALLO-HSCT have a QOL as good as that of a healthy population and the ability to return
to normal life. However, studies thus far are limited to investigations with a few patients with
β-TM who received ALLO-HSCT of the bone marrow (BM) from a sibling donor or related donor.
Graft vs. host disease, patient age, gender, sexual desire, health condition, psychological state, financial
and employment stress, and social support contributed to a worse QOL after ALLO-HSCT.
Medicine usage, physical therapy, and psychological intervention may help improve the decline in
QOL related to ALLO-HSCT in patients with β-TM.
Conclusion: Doctors and nurses must focus on implementing medicine usage, physical therapy,
and psychological intervention to improve the decline in QOL related to ALLO-HSCT.
