Title:Potential Interactions between miRNAs and Hypoxia: A New Layer in Cancer Hypoxia
Volume: 21
Issue: 17
Author(s): Behnam Emamgolizadeh-Gurt Tapeh, Mohammad R. Alivand and Saeed Solalii*
Affiliation:
- Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz,Iran
Keywords:
Hypoxia, miRNAs, cancer, HIF1 alpha, metastasis, signaling pathways.
Abstract: Hypoxia pathway and aberrant miRNA expression profile play crucial roles in the development of
various cancers. Recent studies have emphasized that there are many collaborations in this cases because both
of them are involved in cancer cell processes, including differentiation, metastasis, and cell proliferation and
signaling pathways. Further studies have elucidated that miRNAs affect the hypoxia route, and more interestingly,
the hypoxia pathway also affects miRNAs expression profile. The literature review summarizes the fundamental
roles of hypoxia-related miRNAs in different cancers. The mutual interactions between miRNAs and hypoxia
are a new layer of complexity in cancer hypoxia, which might be helpful in controlling cancer progression.
It is also possible that the hypoxia pathway is initiated by miRNAs. In contrast, the hypoxia pathway regulates
the expression of a large group of miRNAs. In this review for the first time, we discussed the significant
interactions between hypoxia and miRNAs in order to determine new perspectives for new therapeutic aims in
the field of cancer.
