Title:Neurodegenerative Diseases and Flavonoids: Special Reference to Kaempferol
Volume: 20
Issue: 4
Author(s): Rahul and Yasir H. Siddique*
Affiliation:
- Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh,India
Keywords:
Neurodegenerative diseases, kaempferol, Parkinson's disease, flavonoid, blood-brain barrier, Alzheimer's disease.
Abstract: Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, Huntington’s
disease, Multiple Sclerosis and Ischemic stroke have become a major health problem worldwide.
Pre-clinical studies have demonstrated the beneficial effects of flavonoids on neurodegenerative
diseases and suggest them to be used as therapeutic agents. Kaempferol is found in many plants
such as tea, beans, broccoli, strawberries, and neuroprotective effects against the development of
many neurodegenerative diseases such as Parkinson, Alzheimer's disease and Huntington's disease.
The present study summarizes the neuroprotective effects of kaempferol in various models of neurodegenerative
diseases. Kaempferol delays the initiation as well as the progression of neurodegenerative
disorders by acting as a scavenger of free radicals and preserving the activity of various antioxidant
enzymes. Kaempferol can cross the Blood-Brain Barrier (BBB), and therefore results in
an enhanced protective effect. The multi-target property of kaempferol makes it a potential dietary
supplement in preventing and treating neurodegenerative diseases.
