Title:Current Perspectives on the Role of Nrf2 in 5-Fluorouracil Resistance in Colorectal Cancer
Volume: 21
Issue: 17
Author(s): Jiayi Gong and Huaxi Xu*
Affiliation:
- School of Medicine, Jiangsu University, Zhenjiang 212013,China
Keywords:
Colorectal Cancer (CRC), 5-Fluorouracil (5-FU), resistance, Nrf2, repress, medicine, compound.
Abstract:
Background: The antimetabolite, 5-Fluorouracil (5-FU), is the only chemotherapeutic drug to significantly
improve 12-month survival rates of patients with Colorectal Cancer (CRC). However, resistance to 5-FU
is a major obstacle to effective treatment. The mechanism of 5-FU resistance has been discovered but is not fully
known. Nuclear factor-erythroid 2-related factor 2 (Nrf2), a master regulator of cellular defense against
oxidative and electrophilic stresses, is considered a major factor in 5-FU resistance.
Objective: The current study was conducted to discuss the role and mechanisms of Nrf2 in 5-FU resistance and
to search for medicines or compounds that can reverse Nrf2-mediated 5-FU resistance.
Methods: Literature was obtained by defining specific search terms and searching several databases.
Results: Previous study suggested that overactivation of Nrf2 contributed to 5-FU resistance by regulating
many cytoprotective genes. Interestingly, several medicines and compounds can repress 5-FU resistance mediated
of Nrf2.
Conclusion: This review describes the major 5-FU-resistance mechanisms of Nrf2 and summarizes the medicines/
compounds that can overcome them.
