Title:The Therapeutic Potential of Bone Marrow Mesenchymal Stem Cells for Articular Cartilage Regeneration in Osteoarthritis
Volume: 16
Issue: 7
Author(s): Nan Ding, Ermao Li, Xiangbin Ouyang, Jin Guo and Bo Wei*
Affiliation:
- Research Laboratory of Translational Medicine, Hengyang Medical School, University of South China, Hengyang 421001,China
Keywords:
Osteoarthritis, bone marrow mesenchymal stem cells, articular cartilage, inflammatory cytokines, regeneration,
therapeutic potential.
Abstract: Osteoarthritis (OA), characterized by the degeneration and destruction of articular cartilage,
is one of the most significant public health issues around the world. In the course of OA, inflammatory
response is an important factor leading to cartilage destruction and exacerbation of
symptoms. The low immunogenicity, multi-directional differentiation and high portability properties
make bone marrow mesenchymal stem cells (BMSCs) ideal seed cells for OA. Here, we review
recent literature relating to the application of BMSCs for OA cell therapy and consider the following
aspects: migration and homing of BMSCs, immunomodulatory and anti-inflammatory effects
of BMSCs, anti-fibrotic effects of BMSCs, the application of biological scaffolds in cartilage
regeneration by BMSCs and chondrogenic differentiation of BMSCs. Injecting BMSCs into joints
with an inflammatory environment may increase the risk of osteoproliferation and ectopic calcification
in patients. Further evidence and studies are needed to ensure the improvement and maintenance
of the intra-articular environment for cartilage repair and regeneration.
