Title:Biologically Responsive Nanosystems Targeting Cardiovascular Diseases
Volume: 18
Issue: 7
Author(s): Zhiling Song, Kechen Song, Yi Xiao, Hui Guo, Yizhun Zhu*Xiaolin Wang*
Affiliation:
- State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Taipa, Macao,China
- State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Taipa, Macao,China
Keywords:
Biologically responsive, nanosystems, nanoparticle, drug delivery, stimuli-triggered drug release, cardiovascular
diseases.
Abstract: Cardiovascular Diseases (CVD) remain the leading cause of mortality and morbidity
worldwide. To date, significant progress has been made in developing stimuli-responsive nanosystems
that can intrinsically interact with pathological microenvironment to achieve site-specific delivery
along with on-demand drug release for precise CVD treatment. Herein, this review summarizes
recent advances on smart nanosystems in response to a wide range of biological cues, including
pH, enzymes, ROS, shear force, ATP, etc., which can boost drug delivery performance or
monitor disease progression in a non-invasive manner. The designs, compositions and main outcomes
of the single and multi-responsive nanosystems for drug delivery and/or detection purposes
are provided and discussed.
