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Review Article

TL1A:炎症性肠病治疗的一个新的潜在靶点

卷 22, 期 7, 2021

发表于: 20 January, 2021

页: [760 - 769] 页: 10

弟呕挨: 10.2174/1389450122999210120205607

价格: $65

摘要

炎症性肠病(IBD)，包括溃疡性结肠炎(UC)和克罗恩病(CD)，是胃肠道的慢性炎症性疾病。在过去的几年里，针对参与IBD发病机制的细胞因子和受体的生物制剂的发展已经导致了更好的结果，并改善了疾病的病程。尽管肿瘤坏死因子(TNF)抑制剂、抗白细胞介素-12/23和抗整合素等药物有效，但约三分之一的患者没有产生应答，40%的患者随着时间的推移失去应答。因此，需要更有效的治疗。最近的研究表明TL1A (Tumor necrosis factor-like cytokine 1A)作为黏膜免疫的调节因子，参与了IBD发病过程中的免疫通路。在这篇综述中，我们分析TL1A作为一种新的潜在靶点治疗在IBD患者中的作用。

关键词: 溃疡性结肠炎，克罗恩病，炎症性肠病，TL1A

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图形摘要

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