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Review Article

A Comprehensive Review on Pellets as a Dosage Form in Pharmaceuticals

Author(s): Maithri S. Handattu, Shailesh Thirumaleshwar*, Gowrav M. Prakash, Hemanth K. Somareddy and Gangadharappa H. Veerabhadrappa

Volume 22, Issue 10, 2021

Published on: 20 January, 2021

Page: [1183 - 1195] Pages: 13

DOI: 10.2174/1389450122999210120204248

Price: $65

Abstract

Oral route of administration is widely accepted and desired because of its versatility, convenience, and, most importantly, patient compliance. Multiparticulate systems like granules and pellets are more advantageous when compared to single-unit dosage forms, as they are capable of distributing the drug more evenly in the gastrointestinal tract. The current paper focuses on pellets, the merits and demerits associated, various pelletization techniques, and their characterization. It also focuses on how pellets can be employed for drug delivery is controlled and sustained release formulations. It gives a complete emphasis on the drug and excipients that can be used in pellet formation, the marketed formulations, and the research pertaining to pellets.

Keywords: Pellet, Multiple-unit dosage form, Pelletization techniques, Flow property, Immediate release, Sustained release.

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