Title:Delivery of Mesenchymal Stem Cells for Tackling Systemic Disorders
Volume: 16
Issue: 6
Author(s): Wing-Fu Lai*
Affiliation:
- School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172,China
Keywords:
Tissue repair, degenerative disorders, stem cell, systemic administration, delivery technologies, neurological disease.
Abstract: Development of methods for manipulating and culturing stem cells has enabled the emergence
of stem cell therapy as a promising approach in diverse applications, ranging from tissue repair
to treatment of intractable diseases such as diabetes, cardiovascular diseases and neurological disorders.
Along with technological advances in systemic stem cell delivery, treating multiple injured or
pathological sites simultaneously has been made possible. Despite this, most of the works on systemic
stem cell transplantation at the moment have focused on the efficiency of tackling local disorders. The
prospect of the therapy for enhancing systemic tissue repair, as well as for tackling systemic degenerative
disorders, has rarely been seriously considered. The objective of this article is to fill this gap by
reviewing the current status of research on systemic stem cell delivery, and by presenting the opportunities
and challenges for translating systemic stem cell delivery from the laboratory to the clinic.
