Title:Regenerative Medicine Approaches in COVID-19 Pneumonia
Volume: 16
Issue: 6
Author(s): Samira Asgharzade, Akram Alizadeh and Samaneh Arab*
Affiliation:
- Nervous System Stem Cells Research Center, Semnan University of Medical Sciences and Health Services, Semnan,Iran
Keywords:
Regenerative medicine, pneumonia, COVID-19, stem cell, exosome, cell therapy.
Abstract: Regenerative medicine (RM) is an interdisciplinary field that uses different approaches
to accelerate the repair and regeneration or replace damaged or diseased human cells or tissues to
achieve normal tissue function. These approaches include the stimulation of the body’s own repair
processes, transplantation of progenitor cells, stem cells, or tissues, as well as the use of cells and
exosomes as delivery-vehicles for cytokines, genes, or other therapeutic agents. COVID-19 pneumonia
is a specific disease consistent with diffuse alveolar damage resulting in severe hypoxemia.
Therefore, the most serious cause of death from COVID-19 is lung dysfunction. Here, we consider
RM approaches to cure COVID-19 pneumonia based on what RM has so far used to treat lung diseases,
injuries, or pneumonia induced by other pathogens. These approaches include stem and progenitor
cell transplantation, stem cell-derived exosomes, and microRNAs therapy.