Title:Mitophagy in Carcinogenesis and Tumour Progression- A New Paradigm with Emerging Importance
Volume: 21
Issue: 16
Author(s): Suman K. Ray and Sukhes Mukherjee*
Affiliation:
- Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya pradesh-462020,India
Keywords:
Mitophagy, malignant growth, homeostasis, tumour microenvironment, tumour progression, mitochondrial dynamics.
Abstract: The term Mitophagy has been newly concerned in reforming the metabolic landscape inside cancerous
cells in addition to the interface between malignant cells as well as other major constituents of tumour microenvironment.
Several profoundly interrelated systems, comprising mitochondrial dynamics and mitophagy,
function in mammalian cells as vital mitochondrial regulator processes, and their consequence in neoplastic development
has recently been illuminated clinically. In specific instances of cancer cells, mitochondrial-protected
metabolic paths are revamped to meet expanded bioenergetics along with biosynthetic necessities of malignant
cells, in addition to deal with oxidative stress. It is an exhausting task to foresee the role that mitophagy
has on malignant growth cells since it relies upon various elements like cancer variability, malignant growth
phase, genetic background and harmony between cell demand and accessibility. As per condition, mitophagy
may have a double role as cancer suppressor for example Atg5 (autophagy related 5) or Atg7 (autophagy related
7) or execute promoter like function for instance FUNDC1 (FUN14 domain-containing protein 1), BNIP3
(BCL2/adenovirus E1B 19-kDa-interacting protein 3), PINK1 (PTEN-instigated kinase 1) etc. Tumour suppressive
function of Parkin (E3 ubiquitin ligase) is likewise distinguished in mammary gland carcinoma where obstruction
of mitophagy impacts tumour progression. In pancreatic cancer cells and hepatocellular carcinoma hypermethylation
of the BNIP3, promoter occurs that prevent HIF-1 (Hypoxia-Inducible Factor 1) binding besides
ensuing initiation of mitophagy. Since the dual role of mitophagy has in malignant growth relying upon
various circumstances and cell varieties, a range of studies have been performed on mitophagy and its role in
cancer progression and development is opening up a new paradigm with immense clinical importance.
