Title:Anticancer Potential of Azole Containing Marine Natural Products: Current and Future Perspectives
Volume: 21
Issue: 15
Author(s): Dimpy Rani, Vandana Garg and Rohit Dutt*
Affiliation:
- Department of Pharmacy, School of Medical & Allied Sciences, GD Goenka University, Gurugram,India
Keywords:
Anticancer agents, azole, secondary metabolites, oncology research, marine sources, natural products.
Abstract:
Background: Despite significant advancement in oncology research, cancer still poses one of the
leading causes of mortality worldwide. The increased incidences of cancer may be attributed to the limited
efficacy and disastrous side effects of conventional therapies like chemotherapy, radiotherapy and surgery. Azole
containing medicinal agents are known for plethora of medicinal properties, including anticancer potential.
Objective: In this review, we highlighted azole containing natural products with anticancer potential from marine
sources.
Methods: A comprehensive literature search was performed for writing the review. Updated views about various
marine sponges, cyanobacteria, tunicates and microalgae producing azole nucleus containing secondary
metabolites with anticancer potential have been discussed.
Results: The present article describes the structural, chemical, and biological features of azoles containing
natural agents from marine sources with promising anti-cancer potential. Additionally, current challenges and
future perspectives of azoles in cancer prevention and treatment are also discussed.
Conclusion: This review might encourage scientific community to explore marine sources for developing novel
and potent azole containing anti-cancer agents with better safety profile.
