Title:Hydroxychloroquine Sulfate (Plaquenil): A Possible Candidate for Pandemic SARS-CoV-2 or (COVID-19) ?
Volume: 2
Issue: 10
Author(s): Subhash Chandra*, Sarla Saklani and Hassan Y. Aboul-Enein*
Affiliation:
- Department of Pharmaceutical Chemistry, School of Sciences, Hemvati Nandan Bahuguna Garhwal (A Central University) Srinagar Garhwal 246174, Uttarakhand,India
- Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12622,Egypt
Keywords:
HCQ, COVID-19, anti-HIV, anticancer, zika, respiratory diseases.
Abstract: Hydroxychloroquine is a chloroquine derivative recognized for treating ‘SARS-CoV-2
or COVID-19’, among its other uses. It is one of the key drugs used for the treatment of malaria
and other respiratory diseases. The drug exhibits multiple pharmacological activities such as antimalarial,
antidiabetic, anticancer, anti-HIV, antifungal, antimicrobial, and antioxidant activities.
The coronavirus has recently shown five mutations or genetic change in its structure due to change
in the climatic condition (i.e. R 207C (nsp 2-27) – Wuhan (China), V 378 I (nsp 2- 198) – Italy, M 2796I
(nsp 4- 33) – Iran, L 3606F (nsp 6- 37)-America and V 9082F (ORF 7a- 74) – Kuwait). There are many
preclinical, clinical, theoretical, and experimental evidences that support the effectiveness of HCQ
and CQ on patients affected by COVID-19. Based on the evidence currently underway and future
research, we will be able to provide better analysis of the role of HCQ and CQ in the COVID-19
transition. It displays several activities related to the respiratory system, and numerous studies have
suggested that the compound may be beneficial in protection against diseases such as malaria and
lupus erythematosus. The present review represents the role and use of HCQ in the COVID-19 disease.
The object of this review study is based on the research evidence obtained from different authentic
sources. It is currently used in the study of HCQ and CQ for the treatment of coronavirus
and various other infections.
