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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Mini-Review Article

Novel GABAA Agonist Entities: Pharmacological Investigation and Molecular Modeling Study of Thiazolo- and Thiadiazolo-[3,2-a][1,3]diazepine Analogs

Author(s): Hussein I. El-Subbagh*

Volume 21, Issue 9, 2021

Published on: 30 December, 2020

Page: [1048 - 1057] Pages: 10

DOI: 10.2174/1389557521999201230195733

Price: $65

Abstract

Thiazolo- and thiadiazolo-[3,2-a][1,3]diazepines and their patented derivatives, tested with diverse CNS pharmacological activities, constitute an important class of compounds for new drug development. Therefore, research efforts were continued to design, synthesize, and evaluate compounds for their ultra-short, short-acting hypnotic, anticonvulsant, and neuromuscular blocking activities. The present review provides a summary of the work accomplished by these heterocycles and their biological evaluation.

Keywords: Thiazolo[3, 2-a][1, 3]diazepines, thiadiazolo[3, 2-a][1, 3]diazepines, ultra-short-acting hypnotics, short-acting hypnotics, anticonvulsants, neuromuscular blockers, molecular modeling studies.

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