Title:Nanosuspensions - An Update on Recent Patents, Methods of Preparation, and Evaluation Parameters
Volume: 15
Issue: 4
Author(s): Harpreet K. Khanuja, Rajendra Awasthi, Meenu Mehta, Saurabh Satija, Alaa A.A. Aljabali, Murtaza M. Tambuwala, Dinesh K. Chellappan, Kamal Dua and Harish Dureja*
Affiliation:
- Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak,India
Keywords:
Nanosuspension, colloidal, stability, spin coating, high-pressure homogenization, dissolution rate.
Abstract:
Background: Nanosuspensions are colloidal systems consisting of pure drug and stabilizers,
without matrix or lyophilized into a solid matrix. Nanosuspensions improve the solubility of
the drug both in the aqueous and organic phases. Nanosuspensions are also known as brick dust molecules,
as they increase the dissolution of a system and improve absorption.
Methods: Extensive information related to nanosuspensions and its associated patents were collected
using Pub Med and Google Scholar.
Results: Over the last decade nanosuspensions have attracted tremendous interest in pharmaceutical
research. It provides unique features including, improved solubility, high drug loading capacity, and
passive targeting. These particles are cost-effective, simple, and have lesser side effects with minimal
dose requirements. However, the stability of nanosuspensions still warrants attention.
Conclusion: Nanosuspensions play a vital role in handling the numerous drug entities with difficult
physico-chemical characteristics such as solubility and can further aid with a range of routes that
include nasal, transdermal, ocular, parenteral, pulmonary etc. This review highlights the relevance of
nanosuspensions in achieving safe, effective and targeted drug delivery.
