Title:Anti-acne Treatment using Nanotechnology based on Novel Drug Delivery System and Patents on Acne Formulations: A Review
Volume: 15
Issue: 4
Author(s): Vandana Singh, Rakesh Redhu, Ravinder Verma, Vineet Mittal and Deepak Kaushik*
Affiliation:
- Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak - 124001, Haryana,India
Keywords:
Acne, treatment of acne, patents on anti-acne formulations, novel drug delivery system, liposomes, microsponges,
hydrogels.
Abstract:
Background: Acne is one of the most infectious diseases related to human skin. This disease
of acne is of higher prevalence in adults. The main causative organism involved in the acne vulgaris
is Propionibacterium acne, which leads to sebum production and follicular hyperkeratinization.
Methods: The scientific data shows inflammatory mediators of genetic factors, stress, physiological
factor, androgens and hormonal changes; all these factors play a major part in the pathophysiology of
acne. Several drugs are currently available for the treatment of Acne like bactericidal, antibiotic and
several others which are directly or indirectly involved in the eradication of acne.
Results: Nanocarrier systems including liposomes, niosomes, microsponges, nano-emulsion and
micro-emulsion, microspheres and solid lipid nanoparticles have emerged as a successful treatment
for acne. In this article, the authors have laid special emphasis on these nanocarriers and the study of
various patents based on novel technologies in this field. The entrapment of the anti-acne drug molecule
into a particular nanocarrier system has been shown to enhance patient compliance and reduction
in side-effects.
Conclusion: The present review article provides an overview of the mechanism, advantages, drawbacks
and various patents associated with the nanocarrier systems involved in acne treatment. Some
state of the art patented and novel technologies such as stem cell secretion technology, sol-gel technology
incorporating microcapsules and ultrasound delivery of nanoparticles for acne treatment, are
also briefly discussed. The patent study on these nanocarriers was done through the worldwide database
of the United States patent office, European patent office and several other official patent information
websites.
