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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Research Article

SARS-CoV-2 人类靶标在肿瘤和非肿瘤肺组织中的表达和临床意义

卷 21, 期 5, 2021

发表于: 07 December, 2020

页: [428 - 442] 页: 15

弟呕挨: 10.2174/1568009620666201207145019

价格: $65

摘要

背景：包括肺癌患者在内的癌症患者的 COVID-19 感染发生率较高。进行这项研究是为了深入了解癌症中 COVID-19 感染频率的增加。 方法：使用不同的生物信息学工具，分析健康和恶性组织中 ACE2 和 TMPRSS2 的表达和甲基化模式，重点关注肺腺癌，并将数据与临床参数和吸烟史相关联。 结果：ACE2 和 TMPRSS2 在 36 个健康组织中异质表达，消化、泌尿和生殖器官中表达水平最高，而对 72 个配对组织的整体分析表明，与正常对应物相比，癌组织中 ACE2 的表达水平显着降低。相比之下，ACE2 而非 TMPRSS2 在 LUAD 中过表达，这与启动子甲基化呈负相关。 ACE2 的这种上调在 LUAD 中具有年龄依赖性，但在正常肺组织中则不然。 TMPRSS2 在非肿瘤肺组织中的表达是异质的，取决于性别和吸烟史，而在吸烟者的 LUAD 中表达下调。癌症进展与降低的 TMPRSS2 但未改变的 ACE2 相关。相比之下，来自不同癌症亚型的肺转移瘤的ACE2和TMPRSS2高于其他部位的器官转移瘤。 TMPRSS2 与 LUAD 患者的生存相关，但与 ACE2 无关。 结论：综合分子分析揭示了 ACE2 和 TMPRSS2 在健康肺与 LUAD 组织中不同性别、年龄和吸烟史的异质性和独特的表达和/或甲基化特征，可能对 COVID-19 疾病有影响。

关键词: COVID-19，转移，肺腺癌，ACE2，TMPRSS2，临床相关性。

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[1]
Liu, J.; Zheng, X.; Tong, Q.; Li, W.; Wang, B.; Sutter, K.; Trilling, M.; Lu, M.; Dittmer, U.; Yang, D. Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV. J. Med. Virol., 2020, 92(5), 491-494.
[http://dx.doi.org/10.1002/jmv.25709] [PMID: 32056249]
[2]
Kahn, J.S.; McIntosh, K. History and recent advances in coronavirus discovery. Pediatr. Infect. Dis. J., 2005, 24(11)(Suppl.), S223-S227.
[http://dx.doi.org/10.1097/01.inf.0000188166.17324.60] [PMID: 16378050]
[3]
Paules, C.I.; Marston, H.D.; Fauci, A.S. coronavirus infections- more than just the common cold. JAMA, 2020, 323(8), 707-708.
[http://dx.doi.org/10.1001/jama.2020.0757] [PMID: 31971553]
[4]
Drosten, C. Is MERS another SARS? Lancet Infect. Dis., 2013, 13(9), 727-728.
[http://dx.doi.org/10.1016/S1473-3099(13)70159-2] [PMID: 23891403]
[5]
Momattin, H.; Mohammed, K.; Zumla, A.; Memish, Z.A.; Al-Tawfiq, J.A. Therapeutic options for Middle East respiratory syndrome coronavirus (MERS-CoV)- possible lessons from a systematic review of SARS-CoV therapy. Int. J. Infect. Dis., 2013, 17(10), e792-e798.
[http://dx.doi.org/10.1016/j.ijid.2013.07.002] [PMID: 23993766]
[6]
Adams, M.J.; Carstens, E.B. Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2012). Arch. Virol., 2012, 157(7), 1411-1422.
[http://dx.doi.org/10.1007/s00705-012-1299-6] [PMID: 22481600]
[7]
Paraskevis, D.; Kostaki, E.G.; Magiorkinis, G.; Panayiotakopoulos, G.; Sourvinos, G.; Tsiodras, S. Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event. Infect. Genet. Evol., 2020, 79
[http://dx.doi.org/10.1016/j.meegid.2020.104212] [PMID: 32004758]
[8]
Guan, W.J.; Ni, Z.Y.; Hu, Y.; Liang, W.H.; Ou, C.Q.; He, J.X.; Liu, L.; Shan, H.; Lei, C.L.; Hui, D.S.C.; Du, B.; Li, L.J.; Zeng, G.; Yuen, K.Y.; Chen, R.C.; Tang, C.L.; Wang, T.; Chen, P.Y.; Xiang, J.; Li, S.Y.; Wang, J.L.; Liang, Z.J.; Peng, Y.X.; Wei, L.; Liu, Y.; Hu, Y.H.; Peng, P.; Wang, J.M.; Liu, J.Y.; Chen, Z.; Li, G.; Zheng, Z.J.; Qiu, S.Q.; Luo, J.; Ye, C.J.; Zhu, S.Y.; Zhong, N.S. China Medical Treatment Expert Group for Covid-19. Clinical Characteristics of Coronavirus Disease 2019 in China. N. Engl. J. Med., 2020, 382(18), 1708-1720.
[http://dx.doi.org/10.1056/NEJMoa2002032] [PMID: 32109013]
[9]
Li, Q.; Guan, X.; Wu, P.; Wang, X.; Zhou, L.; Tong, Y.; Ren, R.; Leung, K.S.M.; Lau, E.H.Y.; Wong, J.Y.; Xing, X.; Xiang, N.; Wu, Y.; Li, C.; Chen, Q.; Li, D.; Liu, T.; Zhao, J.; Liu, M.; Tu, W.; Chen, C.; Jin, L.; Yang, R.; Wang, Q.; Zhou, S.; Wang, R.; Liu, H.; Luo, Y.; Liu, Y.; Shao, G.; Li, H.; Tao, Z.; Yang, Y.; Deng, Z.; Liu, B.; Ma, Z.; Zhang, Y.; Shi, G.; Lam, T.T.Y.; Wu, J.T.; Gao, G.F.; Cowling, B.J.; Yang, B.; Leung, G.M.; Feng, Z. Early transmission dynamics in wuhan, china, of novel coronavirus-infected pneumonia. N. Engl. J. Med., 2020, 382(13), 1199-1207.
[http://dx.doi.org/10.1056/NEJMoa2001316] [PMID: 31995857]
[10]
Chen, N.; Zhou, M.; Dong, X.; Qu, J.; Gong, F.; Han, Y.; Qiu, Y.; Wang, J.; Liu, Y.; Wei, Y.; Xia, J.; Yu, T.; Zhang, X.; Zhang, L. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet, 2020, 395(10223), 507-513.
[http://dx.doi.org/10.1016/S0140-6736(20)30211-7] [PMID: 32007143]
[11]
Kruse, R.L. Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China. F1000 Res., 2020, 9, 72.
[http://dx.doi.org/10.12688/f1000research.22211.2] [PMID: 32117569]
[12]
Chan, J.F.; Yuan, S.; Kok, K.H.; To, K.K.; Chu, H.; Yang, J.; Xing, F.; Liu, J.; Yip, C.C.; Poon, R.W.; Tsoi, H.W.; Lo, S.K.; Chan, K.H.; Poon, V.K.; Chan, W.M.; Ip, J.D.; Cai, J.P.; Cheng, V.C.; Chen, H.; Hui, C.K.; Yuen, K.Y. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet, 2020, 395(10223), 514-523.
[http://dx.doi.org/10.1016/S0140-6736(20)30154-9] [PMID: 31986261]
[13]
Wang, C.; Horby, P.W.; Hayden, F.G.; Gao, G.F. A novel coronavirus outbreak of global health concern. Lancet, 2020, 395(10223), 470-473.
[http://dx.doi.org/10.1016/S0140-6736(20)30185-9] [PMID: 31986257]
[14]
Fung, T.S.; Liu, D.X. Human coronavirus: host-pathogen interaction. Annu. Rev. Microbiol., 2019, 73, 529-557.
[http://dx.doi.org/10.1146/annurev-micro-020518-115759] [PMID: 31226023]
[15]
Menter, T.; Haslbauer, J.D.; Nienhold, R.; Savic, S.; Hopfer, H.; Deigendesch, N.; Frank, S.; Turek, D.; Willi, N.; Pargger, H.; Bassetti, S.; Leuppi, J.D.; Cathomas, G.; Tolnay, M.; Mertz, K.D.; Tzankov, A. Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction. Histopathology, 2020.
[http://dx.doi.org/10.1111/his.14134] [PMID: 32364264]
[16]
Hoffmann, M.; Kleine-Weber, H.; Schroeder, S.; Kruger, N.; Herrler, T.; Erichsen, S.; Schiergens, T. S.; Herrler, G.; Wu, N. H.; Nitsche, A.; Muller, M. A.; Drosten, C.; Pohlmann, S. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Cell, 2020, 181(2), 271-280.
[17]
Zhou, Y.; Vedantham, P.; Lu, K.; Agudelo, J.; Carrion, R., Jr; Nunneley, J.W.; Barnard, D.; Pöhlmann, S.; McKerrow, J.H.; Renslo, A.R.; Simmons, G. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Res., 2015, 116, 76-84.
[http://dx.doi.org/10.1016/j.antiviral.2015.01.011] [PMID: 25666761]
[18]
Simmons, G.; Zmora, P.; Gierer, S.; Heurich, A.; Pöhlmann, S. Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research. Antiviral Res., 2013, 100(3), 605-614.
[http://dx.doi.org/10.1016/j.antiviral.2013.09.028] [PMID: 24121034]
[19]
Xia, Y.; Jin, R.; Zhao, J.; Li, W.; Shen, H. Risk of COVID-19 for patients with cancer. Lancet Oncol., 2020, 21(4), e180.
[http://dx.doi.org/10.1016/S1470-2045(20)30150-9] [PMID: 32142622]
[20]
Sidaway, P. COVID-19 and cancer: what we know so far. Nat. Rev. Clin. Oncol., 2020, 17(6), 336.
[http://dx.doi.org/10.1038/s41571-020-0366-2] [PMID: 32265531]
[21]
Desai, A.; Sachdeva, S.; Parekh, T.; Desai, R. COVID-19 and cancer: lessons from a pooled meta-analysis. JCO Glob Oncol, 2020, 6, 557-559.
[http://dx.doi.org/10.1200/GO.20.00097] [PMID: 32250659]
[22]
Liang, W.; Guan, W.; Chen, R.; Wang, W.; Li, J.; Xu, K.; Li, C.; Ai, Q.; Lu, W.; Liang, H.; Li, S.; He, J. Cancer patients in SARS- CoV-2 infection: a nationwide analysis in China. Lancet Oncol., 2020, 21(3), 335-337.
[http://dx.doi.org/10.1016/S1470-2045(20)30096-6] [PMID: 32066541]
[23]
Yu, J.; Ouyang, W.; Chua, M. L. K.; Xie, C. SARS-CoV-2 Transmission in Patients With Cancer at a Tertiary Care Hospital in Wuhan, China. JAMA Oncol, 2020.
[24]
Dai, M.; Liu, D.; Liu, M.; Zhou, F.; Li, G.; Chen, Z.; Zhang, Z.; You, H.; Wu, M.; Zheng, Q.; Xiong, Y.; Xiong, H.; Wang, C.; Chen, C.; Xiong, F.; Zhang, Y.; Peng, Y.; Ge, S.; Zhen, B.; Yu, T.; Wang, L.; Wang, H.; Liu, Y.; Chen, Y.; Mei, J.; Gao, X.; Li, Z.; Gan, L.; He, C.; Li, Z.; Shi, Y.; Qi, Y.; Yang, J.; Tenen, D.G.; Chai, L.; Mucci, L.A.; Santillana, M.; Cai, H. Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak. Cancer Discov., 2020, 10(6), 783-791.
[PMID: 32345594]
[25]
Peng, L.; Zagorac, S.; Stebbing, J. Managing patients with cancer in the COVID-19 era. Eur. J. Cancer, 2020, 132, 5-7.
[http://dx.doi.org/10.1016/j.ejca.2020.03.028] [PMID: 32302754]
[26]
Cai, H. Sex difference and smoking predisposition in patients with COVID-19. Lancet Respir. Med., 2020, 8(4), e20.
[http://dx.doi.org/10.1016/S2213-2600(20)30117-X] [PMID: 32171067]
[27]
Zou, X.; Chen, K.; Zou, J.; Han, P.; Hao, J.; Han, Z. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front. Med., 2020, 14(2), 185-192.
[http://dx.doi.org/10.1007/s11684-020-0754-0] [PMID: 32170560]
[28]
Lukassen, S.; Chua, R.L.; Trefzer, T.; Kahn, N.C.; Schneider, M.A.; Muley, T.; Winter, H.; Meister, M.; Veith, C.; Boots, A.W.; Hennig, B.P.; Kreuter, M.; Conrad, C.; Eils, R. SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. EMBO J., 2020, 39(10)
[http://dx.doi.org/10.15252/embj.2020105114] [PMID: 32246845]
[29]
Cheng, Q.; Zhou, L.; Zhou, J.; Wan, H.; Li, Q.; Feng, Y. ACE2 overexpression inhibits acquired platinum resistance-induced tumor angiogenesis in NSCLC. Oncol. Rep., 2016, 36(3), 1403-1410.
[http://dx.doi.org/10.3892/or.2016.4967] [PMID: 27460845]
[30]
Feng, Y.; Ni, L.; Wan, H.; Fan, L.; Fei, X.; Ma, Q.; Gao, B.; Xiang, Y.; Che, J.; Li, Q. Overexpression of ACE2 produces antitumor effects via inhibition of angiogenesis and tumor cell invasion in vivo and in vitro. Oncol. Rep., 2011, 26(5), 1157-1164.
[PMID: 21769437]
[31]
Zhang, H.; Quek, K.; Chen, R.; Chen, J.; Chen, B. Expression of the SAR2-Cov-2 receptor ACE2 reveals the susceptibility of COVID-19 in non-small cell lung cancer. J. Cancer, 2020, 11(18), 5289-5292.
[http://dx.doi.org/10.7150/jca.49462] [PMID: 32742475]
[32]
Chai, P.; Yu, J.; Ge, S.; Jia, R.; Fan, X. Genetic alteration, RNA expression, and DNA methylation profiling of coronavirus disease 2019 (COVID-19) receptor ACE2 in malignancies: a pan-cancer analysis. J. Hematol. Oncol., 2020, 13(1), 43.
[http://dx.doi.org/10.1186/s13045-020-00883-5] [PMID: 32366279]
[33]
Kong, Q.; Xiang, Z.; Wu, Y.; Gu, Y.; Guo, J.; Geng, F. Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection. Mol. Cancer, 2020, 19(1), 80.
[http://dx.doi.org/10.1186/s12943-020-01209-2] [PMID: 32345328]
[34]
Park, S.J.; Yoon, B.H.; Kim, S.K.; Kim, S.Y. GENT2: an updated gene expression database for normal and tumor tissues. BMC Med. Genomics, 2019, 12(Suppl. 5), 101.
[http://dx.doi.org/10.1186/s12920-019-0514-7] [PMID: 31296229]
[35]
Cerami, E.; Gao, J.; Dogrusoz, U.; Gross, B.E.; Sumer, S.O.; Aksoy, B.A.; Jacobsen, A.; Byrne, C.J.; Heuer, M.L.; Larsson, E.; Antipin, Y.; Reva, B.; Goldberg, A.P.; Sander, C.; Schultz, N. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov., 2012, 2(5), 401-404.
[http://dx.doi.org/10.1158/2159-8290.CD-12-0095] [PMID: 22588877]
[36]
Gao, J.; Aksoy, B.A.; Dogrusoz, U.; Dresdner, G.; Gross, B.; Sumer, S.O.; Sun, Y.; Jacobsen, A.; Sinha, R.; Larsson, E.; Cerami, E.; Sander, C.; Schultz, N. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci. Signal., 2013, 6(269), pl1.
[http://dx.doi.org/10.1126/scisignal.2004088] [PMID: 23550210]
[37]
Shi, J.; Marconett, C.N.; Duan, J.; Hyland, P.L.; Li, P.; Wang, Z.; Wheeler, W.; Zhou, B.; Campan, M.; Lee, D.S.; Huang, J.; Zhou, W.; Triche, T.; Amundadottir, L.; Warner, A.; Hutchinson, A.; Chen, P.H.; Chung, B.S.; Pesatori, A.C.; Consonni, D.; Bertazzi, P.A.; Bergen, A.W.; Freedman, M.; Siegmund, K.D.; Berman, B.P.; Borok, Z.; Chatterjee, N.; Tucker, M.A.; Caporaso, N.E.; Chanock, S.J.; Laird-Offringa, I.A.; Landi, M.T. Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. Nat. Commun., 2014, 5, 3365.
[http://dx.doi.org/10.1038/ncomms4365] [PMID: 24572595]
[38]
Bhandari, V.; Hoey, C.; Liu, L.Y.; Lalonde, E.; Ray, J.; Livingstone, J.; Lesurf, R.; Shiah, Y.J.; Vujcic, T.; Huang, X.; Espiritu, S.M.G.; Heisler, L.E.; Yousif, F.; Huang, V.; Yamaguchi, T.N.; Yao, C.Q.; Sabelnykova, V.Y.; Fraser, M.; Chua, M.L.K.; van der Kwast, T.; Liu, S.K.; Boutros, P.C.; Bristow, R.G. Molecular landmarks of tumor hypoxia across cancer types. Nat. Genet., 2019, 51(2), 308-318.
[http://dx.doi.org/10.1038/s41588-018-0318-2] [PMID: 30643250]
[39]
Ellrott, K.; Bailey, M. H.; Saksena, G.; Covington, K. R.; Kandoth, C.; Stewart, C.; Hess, J.; Ma, S.; Chiotti, K. E.; McLellan, M.; Sofia, H. J.; Hutter, C.; Getz, G.; Wheeler, D.; Ding, L.; Group, M. C. W. Cancer Genome Atlas Research, N., Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines. Cell Syst, 2018, 6(3), 271-281.
[40]
Gao, Q.; Liang, W. W.; Foltz, S. M.; Mutharasu, G.; Jayasinghe, R. G.; Cao, S.; Liao, W. W.; Reynolds, S. M.; Wyczalkowski, M. A.; Yao, L.; Yu, L.; Sun, S. Q.; Fusion Analysis Working, G.; Chen, K; Lazar, A.J; Fields, R.C; Wendl, M.C; Van Tine, B.A; Vij, R.; Chen, F.; Nykter, M.; Shmulevich, I; Ding, L. Cancer genome atlas research, n.driver fusions and their implications in the development and treatment of human cancers Cell Rep, 2018, 23(1), 227-238.
[41]
Hoadley, K. A.; Yau, C.; Hinoue, T.; Wolf, D. M.; Lazar, A. J.; Drill, E.; Shen, R.; Taylor, A. M.; Cherniack, A. D.; Thorsson, V.; Akbani, R.; Bowlby, R.; Wong, C. K.; Wiznerowicz, M.; Sanchez-Vega, F.; Robertson, A. G.; Schneider, B. G.; Lawrence, M. S.; Noushmehr, H.; Malta, T. M.; Cancer Genome Atlas, N.; Stuart, J. M.; Benz, C. C.; Laird, P. W. Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer Cell, 2018, 173(2), 291-304.
[42]
Liu, J.; Lichtenberg, T.; Hoadley, K. A.; Poisson, L. M.; Lazar, A. J.; Cherniack, A. D.; Kovatich, A. J.; Benz, C. C.; Levine, D. A.; Lee, A. V.; Omberg, L.; Wolf, D. M.; Shriver, C. D.; Thorsson, V.; Hu, H. Cancer genome atlas research, n.an integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics Cell , 2018, 173(2), 400-416.
[43]
Sanchez-Vega, F.; Mina, M.; Armenia, J.; Chatila, W. K.; Luna, A.; La, K. C.; Dimitriadoy, S.; Liu, D. L.; Kantheti, H. S.; Saghafinia, S.; Chakravarty, D.; Daian, F.; Gao, Q.; Bailey, M. H.; Liang, W. W.; Foltz, S. M.; Shmulevich, I.; Ding, L.; Heins, Z.; Ochoa, A.; Gross, B.; Gao, J.; Zhang, H.; Kundra, R.; Kandoth, C.; Bahceci, I.; Dervishi, L.; Dogrusoz, U.; Zhou, W.; Shen, H.; Laird, P. W.; Way, G. P.; Greene, C. S.; Liang, H.; Xiao, Y.; Wang, C.; Iavarone, A.; Berger, A. H.; Bivona, T. G.; Lazar, A. J.; Hammer, G. D.; Giordano, T.; Kwong, L. N.; McArthur, G.; Huang, C.; Tward, A. D.; Frederick, M. J.; McCormick, F.; Meyerson, M. Oncogenic signaling pathways in the cancer genome atlas Cell, 2018, 173(2), 321-337.
[44]
Taylor, A. M.; Shih, J.; Ha, G.; Gao, G. F.; Zhang, X.; Berger, A. C.; Schumacher, S. E.; Wang, C.; Hu, H.; Liu, J.; Lazar, A. J.; Cherniack, A. D.; Beroukhim, R.; Meyerson, M. Cancer Genome Atlas Research, N.Genomic and Functional Approaches to Understanding Cancer Aneuploidy Cancer Cell, 2018, 33(4), 676-6989.
[45]
Cai, L.; Lin, S.; Girard, L.; Zhou, Y.; Yang, L.; Ci, B.; Zhou, Q.; Luo, D.; Yao, B.; Tang, H.; Allen, J.; Huffman, K.; Gazdar, A.; Heymach, J.; Wistuba, I.; Xiao, G.; Minna, J.; Xie, Y. LCE: an open web portal to explore gene expression and clinical associations in lung cancer. Oncogene, 2019, 38(14), 2551-2564.
[http://dx.doi.org/10.1038/s41388-018-0588-2] [PMID: 30532070]
[46]
Chandrashekar, D.S.; Bashel, B.; Balasubramanya, S.A.H.; Creighton, C.J.; Ponce-Rodriguez, I.; Chakravarthi, B.V.S.K.; Varambally, S. UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia, 2017, 19(8), 649-658.
[http://dx.doi.org/10.1016/j.neo.2017.05.002] [PMID: 28732212]
[47]
Zheng, G.; Ma, Y.; Zou, Y.; Yin, A.; Li, W.; Dong, D. HCMDB: the human cancer metastasis database. Nucleic Acids Res., 2018, 46(D1), D950-D955.
[http://dx.doi.org/10.1093/nar/gkx1008] [PMID: 29088455]
[48]
Okayama, H.; Kohno, T.; Ishii, Y.; Shimada, Y.; Shiraishi, K.; Iwakawa, R.; Furuta, K.; Tsuta, K.; Shibata, T.; Yamamoto, S.; Watanabe, S.; Sakamoto, H.; Kumamoto, K.; Takenoshita, S.; Gotoh, N.; Mizuno, H.; Sarai, A.; Kawano, S.; Yamaguchi, R.; Miyano, S.; Yokota, J. Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas. Cancer Res., 2012, 72(1), 100-111.
[http://dx.doi.org/10.1158/0008-5472.CAN-11-1403] [PMID: 22080568]
[49]
Gebhard, C.; Regitz-Zagrosek, V.; Neuhauser, H.K.; Morgan, R.; Klein, S.L. Impact of sex and gender on COVID-19 outcomes in Europe. Biol. Sex Differ., 2020, 11(1), 29.
[http://dx.doi.org/10.1186/s13293-020-00304-9] [PMID: 32450906]
[50]
Zhang, L.; Zhu, F.; Xie, L.; Wang, C.; Wang, J.; Chen, R.; Jia, P.; Guan, H. Q.; Peng, L.; Chen, Y.; Peng, P.; Zhang, P.; Chu, Q.; Shen, Q.; Wang, Y.; Xu, S. Y.; Zhao, J. P.; Zhou, M. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. Ann Oncol, 2020.
[51]
Zhang, H.; Xie, C.; Huang, Y. Treatment and outcome of a patient with lung cancer infected with severe acute respiratory syndrome coronavirus-2. J. Thorac. Oncol., 2020, 15(5), e63-e64.
[http://dx.doi.org/10.1016/j.jtho.2020.02.025] [PMID: 32147577]
[52]
Yang, X.; Tan, B.; Zhou, X.; Xue, J.; Zhang, X.; Wang, P.; Shao, C.; Li, Y.; Li, C.; Xia, H.; Qiu, J. Interferon-inducible transmembrane protein 3 genetic variant rs12252 and influenza susceptibility and severity: a meta-analysis. PLoS One, 2015, 10(5)
[http://dx.doi.org/10.1371/journal.pone.0124985] [PMID: 25942469]
[53]
Li, M.Y.; Li, L.; Zhang, Y.; Wang, X.S. Expression of the SARS- CoV-2 cell receptor gene ACE2 in a wide variety of human tissues. Infect. Dis. Poverty, 2020, 9(1), 45.
[http://dx.doi.org/10.1186/s40249-020-00662-x] [PMID: 32345362]
[54]
Zhou, P.; Yang, X.L.; Wang, X.G.; Hu, B.; Zhang, L.; Zhang, W.; Si, H.R.; Zhu, Y.; Li, B.; Huang, C.L.; Chen, H.D.; Chen, J.; Luo, Y.; Guo, H.; Jiang, R.D.; Liu, M.Q.; Chen, Y.; Shen, X.R.; Wang, X.; Zheng, X.S.; Zhao, K.; Chen, Q.J.; Deng, F.; Liu, L.L.; Yan, B.; Zhan, F.X.; Wang, Y.Y.; Xiao, G.F.; Shi, Z.L. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 2020, 579(7798), 270-273.
[http://dx.doi.org/10.1038/s41586-020-2012-7] [PMID: 32015507]
[55]
Li, G.; He, X.; Zhang, L.; Ran, Q.; Wang, J.; Xiong, A.; Wu, D.; Chen, F.; Sun, J.; Chang, C. Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19. J. Autoimmun., 2020, 112
[http://dx.doi.org/10.1016/j.jaut.2020.102463] [PMID: 32303424]
[56]
Qian, Y.R.; Guo, Y.; Wan, H.Y.; Fan, L.; Feng, Y.; Ni, L.; Xiang, Y.; Li, Q.Y. Angiotensin-converting enzyme 2 attenuates the metastasis of non-small cell lung cancer through inhibition of epithelial-mesenchymal transition. Oncol. Rep., 2013, 29(6), 2408-2414.
[http://dx.doi.org/10.3892/or.2013.2370] [PMID: 23545945]
[57]
Stebbing, J.; Atkins, M.; Nelson, M.; Rajpopat, S.; Newsom- Davis, T.; Gazzard, B.; Bower, M. Hepatitis B reactivation during combination chemotherapy for AIDS-related lymphoma is uncommon and does not adversely affect outcome. Blood, 2004, 103(6), 2431-2432.
[http://dx.doi.org/10.1182/blood-2003-12-4222] [PMID: 14998920]
[58]
Shang, L.; Zhao, J.; Hu, Y.; Du, R.; Cao, B. On the use of corticosteroids for 2019-nCoV pneumonia. Lancet, 2020, 395(10225), 683-684.
[http://dx.doi.org/10.1016/S0140-6736(20)30361-5] [PMID: 32122468]
[59]
Russell, C.D.; Millar, J.E.; Baillie, J.K. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. Lancet, 2020, 395(10223), 473-475.
[http://dx.doi.org/10.1016/S0140-6736(20)30317-2] [PMID: 32043983]
[60]
Farsalinos, K.; Barbouni, A.; Niaura, R. Systematic review of the prevalence of current smoking among hospitalized COVID-19 patients in China: could nicotine be a therapeutic option? Intern. Emerg. Med., 2020.

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