Title:Outbreak of Respiratory Infection: nCoV-2019 Current Status and Its Impact on Global Health
Volume: 16
Issue: 3
Author(s): Saurabh Kumar*, Sandeep Kumar, Adil Karim, Kamlesh Bisht, Abdul Ghani and Vimal Singh Munda
Affiliation:
- Department of Science & Technology (DST) - Centre for Policy Research, Indian Institute of Science (IISc), Bengaluru, Karnataka 560012,India
Keywords:
nCoV-2019, SARS, epidemiology, pandemic, infection, global health.
Abstract: Novel coronavirus-2019 (nCoV-2019) emerged as a potentially infectious respiratory
disease caused by newly discovered β-coronavirus. nCoV-19 has emerged as a global pandemic
due to the rapid transmission and high infection rate commonly involved in acute respiratory illness.
Literature search includes various databases like Google Scholar, PubMed, ScienceDirect,
and Scopus for studies published using a different combination of keywords “coronavius”,
“COVID-19”, “SARS”, “MERS”, “antiviral drugs”, “vaccines”, and “immunity”. We collected epidemiology
data from the Worldometer portal (data available till 9 October, 2020). Fever, dry
cough, dyspnea, sore throat, or fatigue are common clinical symptoms of the infection. Cytotoxic
T-cells and T-helper cells plus Cytotoxic T cells (CD8+) account for maximum (approximately
80%) of total infiltrate in the pulmonary region of the affected nCoV individuals and act as a significant
contributor to the clearance of the infection. This review intends to outline the literature concerning
the mode of actual transmission, immune response, and possible therapeutic approach
against the virus.
