Title:Isatin: A Scaffold with Immense Biodiversity
Volume: 21
Issue: 9
Author(s): Priyobrata Nath, Agnish Mukherjee, Sougata Mukherjee, Sabyasachi Banerjee, Samarpita Das and Subhasis Banerjee*
Affiliation:
- Department of Pharmaceutical Chemistry, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol 713301 West Bengal,India
Keywords:
Isatin, anti-microbial, anticonvulsant, anti-cancer, anti-tubercular, anti-inflammatory.
Abstract: Isatin is an endogenous and a significant category of fused heterocyclic components and
has widely been a part of several potential biologically useful synthetics. Since its discovery, tons of
research work has been conducted with respect to the synthesis, chemical properties, and biological
and industrial applications. It contains an indole nucleus having both lactam and keto moiety, which,
while being a part of a molecular framework, exerted several biological effects, viz.; anti-microbial,
anti-tubercular, anticonvulsant, anti-cancer, etc. Isatin derivatives are synthetically significant substrates,
which can be utilized for the synthesis of huge diversified chemical entities of which few
members emerged as drugs. The reason for this review is to provide extensive information pertaining
to the chemistry and its significance in altering several pathological states of isatin and its derivatives.
A Structure-Activity Relationship study thus developed through a gamut of scientific information indicates
the importance of mostly electron-withdrawing groups, halogens, nitro, alkoxy, and, to a minor
extent, groups with positive inductive effects, such as methyl at position 1, 5, 6 and 7 of isatin in
alleviating several clinical conditions. It is also observed from the survey that the presence of two oxo
groups at positions 2 and 3 sometimes becomes insignificant as a fusion with a heterocycle at these
positions resulted in a biologically relevant compound.
