Title:Potential Roles of MyomiRs in Cardiac Development and Related Diseases
Volume: 17
Issue: 4
Author(s): Leila Abkhooie, Mostafa M. Sarabi*, Houman Kahroba, Shirin Eyvazi, Soheila Montazersaheb, Vahideh Tarhriz*Mohammad S. Hejazi
Affiliation:
- Department of Biochemistry and Genetics, School of Medicine, Lorestan University of Medical Science, Khorramabad,Iran
- Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz,Iran
Keywords:
MyomiRs, epigenetic, cardiac development, cardiac diseases, microRNA, cardiac regeneration.
Abstract: Muscle-specific miRNAs, which are known as MyomiRs, are crucial regulatory elements
for cardiovascular development. MyomiRs are abundantly expressed in the myocardium and
regulate certain aspects of physiological and pathological processes in myocardiocytes, including
cardiovascular development, myocardial remodeling, and arise for cardiovascular diseases through
different mechanisms, such as epigenetic pathways. Clinical and experimental studies have confirmed
the myomiRs as promising diagnostic biomarkers for the early diagnosis of cardiac disorders.
In this review, we have summarized recent findings in the field of epigenetic modulations of
myomiRs and cardiac regeneration associated with cardiac diseases.
