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The Natural Products Journal

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ISSN (Online): 2210-3163

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Review Article

Chitosan Nanoparticles: An Approbative System for the Delivery of Herbal Bioactives

Author(s): Sapna Saini, Sanju Nanda* and Anju Dhiman

Volume 12, Issue 1, 2022

Published on: 24 November, 2020

Article ID: e160921188333 Pages: 14

DOI: 10.2174/2210315510999201124155627

Price: $65

Abstract

Chitosan, a natural biodegradable polymer obtained from deacetylation of chitin, has been used as an approbative macromolecule for the development of various novel drug delivery systems. It is one of the most favorable biodegradable carriers for nanoparticulate drug delivery due to its intrinsic properties, such as biocompatibility, biodegradability, non-toxicity, availability of free reactive amino groups, and ease of chemical modification into different active derivatives. Furthermore, interesting physical properties (film-forming, gelling and thickening) make it a suitable candidate for formulations, such as films, microcapsules, beads, nanoparticles, nanofibres, nanogel, and so on. Researchers have reported that chitosan nanoparticles act as a promising vehicle for herbal actives as they provide a superior alternative to traditional carriers and improve pharmaceutical efficiency. As no review of chitosan nanoparticles encapsulating herbal extracts and bioactives has been published to date, a maiden effort has been made to collate and review the use of chitosan nanoparticles for the entrapment of phytoconstituents to yield stable, efficient, and safe drug delivery systems. Additionally, the paper presents a comprehensive account of the state-of the-art in fabricating herbal chitosan nanoparticles and their current pharmacological status. A list of patents on chitosan nanoparticles of herbal actives has also been included. This review is intended to serve as a didactic discourse for the formulation scientists endeavoring to develop advanced delivery systems for herbal actives.

Keywords: Bioavailability, biodegradable polymer, chitosan, herbal bioactives, nanoparticles, novel drug delivery system.

Graphical Abstract

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