Title:Hepatocyte Growth Factor and Insulin-like Growth Factor-1 based Cellular Therapies for Oxidative Stress Injury
Volume: 16
Issue: 7
Author(s): Ozge Burcu Sahan and Aysen Gunel-Ozcan*
Affiliation:
- Department of Stem Cell Sciences, Graduate School of Health Sciences, Hacettepe University, Ankara,Turkey
Keywords:
Oxidative stress, reactive oxygen species, mesenchymal stem cells, preconditioning, insulin-like growth factor,
hepatocyte growth factor.
Abstract: Imbalance between free radicals and antioxidants causes oxidative stress by the accumulation
of reactive oxygen species (ROS) in the tissues and organs. Oxidative stress occurs in many damaged
conditions, and the increase of ROS and reduction of antioxidants enhances inflammation, apoptosis,
fibrosis and may worsen the pathology leading to organ failure. The potential therapies aim to
increase antioxidants and decrease ROS. Mesenchymal stem cells (MSCs) isolated from the stroma of
various tissues are multipotent cells and have beneficial effects on several diseases with their immunomodulation
and regeneration capacities. MSCs trigger the proliferation of the cells with various
secretory factors, reduce oxidative stress and decrease apoptosis, inflammation, fibrosis and thus, increase
regeneration. However, survival, engraftment, and differentiation problems of transplanted
MSCs restrict their protective and regenerative effects. Preconditioning of MSCs with several factors,
such as cytokines, hypoxia, chemical agents, pharmacological drugs, physical factors and growth factors,
enhances their repairing efficacy for injury and disease models. This review is mainly focused on
insulin-like growth factor (IGF-1) and hepatocyte growth factor (HGF), and discusses the research on
MSC priming/induction with IGF-1 and HGF stimulation either by supplementation or overexpression
that can enhance the regenerative potential of MSCs on various oxidative stress conditions such as
acute/chronic kidney diseases, lung injury, cancer, metabolic and cardiovascular diseases.
