Title:Targeting Tumor-derived Exosomes Expressing CD73: New Opportunities in the Pathogenesis and Treatment of Cancer
Volume: 21
Issue: 6
Author(s): Vajihe T. Nooshabadi and Samaneh Arab*
Affiliation:
- Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan,Iran
Keywords:
Tumor-derived exosome, CD73, CD39, adenosine, cancer progression, pathogenesis.
Abstract: Tumor-derived exosomes contain biological contents such as proteins, lipids,
RNA (miRNAs, mRNAs, lncRNA), and DNA for intracellular communication. Meanwhile,
studies have shown the role of exosomes in cancer progression, metastasis, and
therapeutic resistance. Furthermore, tumor exosomes have received growing attention
due to their potential as novel therapeutic protocols for the treatment of cancers.
Adenosine nucleoside, which is a derivative of ATP, is highly elevated in the tumor
microenvironment by CD39 and CD73 enzymatic activity. Recently, it is distinguished
that cancer cell-derived exosomes carry CD39 and CD73 on their surface and may
contribute to rising adenosine levels in the tumor microenvironment. In this review, we
summarize the evidence of CD39/CD73-bearing exosomes and their role in cancer
development, progression, invasion, angiogenesis, metastasis and their application in
the selection of the appropriate strategy to treat different types of cancer.
