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Mini-Review Article

靶向基因异常治疗结肠癌及其转移进展

卷 22, 期 7, 2021

发表于: 19 November, 2020

页: [722 - 733] 页: 12

弟呕挨: 10.2174/1389450121666201119141015

价格: $65

摘要

结直肠癌的发生涉及从遗传改变积累到遗传和表观遗传调节和染色体异常的各种过程。它还涉及致癌基因和肿瘤抑制基因的突变。基因组不稳定性在结直肠癌中起着至关重要的作用。现代生物学技术的进步和分子水平的研究已经确定了各种参与结直肠癌(CRC)的基因。KRAS、BRAF、PI3K和p53基因在CRC的不同阶段发挥重要作用。这些基因的改变导致结肠癌的发生、发展和转移。本文就KRAS、BRAF、PI3KCA和TP53基因在结直肠癌发病中的作用及其在结直肠癌各阶段的意义进行综述。它还提供了对作用于这些基因的特定调节器的见解。此外，这篇综述还讨论了这些基因在致癌过程中通路的机制，以及当前的分子和在不同临床评估阶段的治疗方案。

关键词: 转移性结肠癌，基因改变，BRAF基因，KRAS基因，P53基因，PI3K基因

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图形摘要

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