Title:The Association between Migraine and Depression based on miRNA Biomarkers and Cohort Studies
Volume: 28
Issue: 27
Author(s): Yi-Hau Chen and Hsiuying Wang*
Affiliation:
- Institute of Statistics, National Chiao Tung University, Hsinchu,Taiwan
Keywords:
Biomarker, major depression, migraine, microRNA, epidemiological study, comorbidity.
Abstract:
Background: An association between migraine and Major Depression (MD)
has been revealed in a number of clinical studies. Both diseases have affected a large
global population. More understanding of the comorbidity mechanism of these two diseases
can shed light on developing new therapies for their treatment.
Methods: To the best of our knowledge, there have not been any researches in the literature
based on microRNA (miRNA) biomarkers to investigate the relationship between
MD and migraine. In this study, we have discussed the association between these two diseases
based on their miRNA biomarkers. In addition to miRNA biomarkers, we have also
demonstrated epidemiological evidence for their association based on Taiwan
Biobank (TWB) data.
Results: Among the 12 migraine miRNA biomarkers, 11 are related to MD. Only
miR-181a has no direct evidence to be involved in the mechanism of MD. In addition to
the biological biomarker evidence, the statistical analysis using the large-scale epidemiologic
data collected from TWB provides strong evidence on the relationship between MD
and migraine.
Conclusion: The evidence based on both molecular and epidemiological data reveals the
significant association between MD and migraine. This result can help investigate the correlated
underlying mechanism of these two diseases.