Title:Regulation of Runx2 and Its Signaling Pathways by MicroRNAs in Breast Cancer Metastasis
Volume: 22
Issue: 7
Author(s): Shivashankar Pranavkrishna, Ganesh Sanjeev, Ravishkumar L. Akshaya, Muthukumar Rohini and Nagarajan Selvamurugan*
Affiliation:
- Department of Biotechnology, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu,India
Keywords:
Breast pathogenesis, non-coding RNAs, osteolytic metastasis, post-transcriptional regulation, signal transduction,
transcription factor.
Abstract: As a major threat among women globally, breast cancer (BC) emerges as a primary research
focus for several researchers. Although various therapeutic regimens are available, there is
an increased chance of metastasis of BC cells, which raises the severity of this malignancy. Of multiple
preferred secondary targets, metastasis to bone is extensively studied. Besides deemed as a
bone transcription factor, Runx2 also acts as a metastatic factor that promotes growth and metastasis
of BC cells. Studies have reported the significant role of microRNAs (miRNAs) in BC pathogenesis
and metastasis by governing Runx2 expression. Additionally, dysregulation of the signaling
pathways, including Wnt/β-catenin, TGF-β, Notch, and PI3K/AKT, has been observed to influence
the expression of Runx2 in BC cells. In this review, we have aimed to highlight the regulatory role
of miRNAs in targeting Runx2 both directly and indirectly by governing respective signaling pathways
during bone metastasis of BC.
