Title:Potential Role of In Vitro-In Vivo Correlations (IVIVC) for the Development of Plant-Derived Anticancer Drugs
Volume: 22
Issue: 12
Author(s): Mohamed S.T.A. Azeeze*, Shanthi B. Santhosh, Murugesan S. Manjari and Subramania N. Meyyanathan
Affiliation:
- Department of Pharmaceutical Analysis, JSS College of Pharmacy (A Constituent College of JSS Academy of higher education and research), Ooty-643001, Tamilnadu,India
Keywords:
Cancer, chemotherapy, In Vitro-In Vivo correlation (IVIVC), herbal drugs, anticancer agents, treatments.
Abstract:
Background: Conventional medicines, along with herbal formulations of Chinese, serve
as the primary source and hub of active new drugs where the initial research concentrates on the extraction
and isolation of bioactive lead compound(s) to treat several diseases largely for cancer.
Plant-derived natural products and their analogs reveal a significant source of several clinically useful
anticancer agents. Herbs and herbal derived active compounds play an unavoidable role in the
treatment, drug discovery and delivery for decades, as evidenced by numerous existing marked
drugs and various cancer-related molecular targets in clinical development.
Objective: Solubility, resistance and metabolic limitations of the drug can be overcome by suitable
molecular modifications. Due to enhancements in tumor targeting technology, some agents who
failed in earlier clinical studies are also stimulating renewed interest. In this connection, In Vitro-In
Vivo Correlation (IVIVC) plays an important role in the development of dosage forms in the field
of pharmaceutical technology.
Conclusion: IVIVC tool fastens and improves the drug development process and product quality,
which is also utilized in internal control for scale-up to improve formulations and alternative production
processes. Most importantly, this IVIVC tool lessens the number of human studies during
new pharmaceuticals developments. In this review, we would like to grab the attention of readers
to the importance and significance of IVIVC for natural products of anticancer drugs examples
such as Docetaxel, Etoposide phosphate, 6-Gingerol, Capsaicin, etc.
