Title:Current Updates in Transdermal Therapeutic Systems and Their Role in Neurological Disorders
Volume: 22
Issue: 6
Author(s): Neelu Yadav, Ashu Mittal*, Javed Ali and Jagannath Sahoo
Affiliation:
- Department of Pharmaceutics, KIET School of Pharmacy (KIET Group of Institutions), Ghaziabad, Uttar Pradesh,India
Keywords:
Transdermal delivery, novel enhancers, neurological disorders, nanotechnologies, transdermal therapeutic systems,
alzheimer's disease.
Abstract: The transdermal therapeutic system plays an important role in the treatment of neuropathic
pain. Transdermal drug delivery is considered an ideal therapeutic approach for the management
of chronic neurological disorders in the elderly population. It is a simple to use, non-invasive
and painless drug delivery system, which provides sustained therapeutic plasma levels of drug for
an extended period. Moreover, it bypasses the first-pass metabolism of the active agent, improves
bioavailability and reduces undesired adverse effects, which in turn improves patient compliance.
Several transdermal delivery systems are currently under investigation for the treatment of Parkinson’s
syndrome, Alzheimer’s disorders, and Neurological pain. Drug delivery via the transdermal
route is proposed as an alternative remedy to overcome the drawbacks associated with the conventional
dosage forms for chronic neurological disorders. The management of Alzheimer’s disease
via transdermal drug administration exhibits the greatest therapeutic improvements in the treatment
of cognition and global functioning among neuropathic patients. Technological breakthroughs in
transdermal drug administration such as the microreservior system, microneedles, metered-dose
transdermal spray (MDTS), needle-free injections, and ultrasound-based transdermal therapeutic
systems have been successfully used to treat neurological disorders. For example, microneedle (MN)
is a highly efficient and versatile device due to its distinctive properties. Ultrasounds have been
very popular for the delivery of bioactive agents across the skin barrier. This review focuses on the
recent advances of various technologies employed in the transdermal therapeutic systems and their
applications on neurological disorders for achieving therapeutic outcomes on patients.
