Title:Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry
Volume: 17
Issue: 10
Author(s): Vitor F. Ferreira*, Alcione S. de Carvalho, Patricia G. Ferreira, Carolina G.S. Lima and Fernando de C. da Silva
Affiliation:
- Universidade Federal Fluminense, Faculdade de Farmacia, Departamento de Tecnologia Farmaceutica, Niteroi, 24241-000, RJ,Brazil
Keywords:
Atovaquone, buparvaquone, parvaquone, mitomycins, doxorubicin, valrubicin, mitoxantrone.
Abstract:
Background: Several quinones are on the pharmaceutical market as drugs for the treatment
of several diseases.
Objective: The aim of this review was to provide an overview of the quinones that have become
drugs for several therapeutic applications.
Methods: We have comprehensively and critically discussed all the information available in the literature
about quinone-based drugs.
Results: In this review, the various aspects of the chemistry and biochemistry of these drugs are highlighted,
including their repositioning, drug combination and their new uses.
Conclusion: A number of studies related to quinone drugs for different pharmaceutical uses show
that the interest in new applications is still increasing in recent years.
