Title:Medicinal Research Progress of Natural Coumarin and its Derivatives
Volume: 11
Issue: 5
Author(s): Aadil Khursheed*Vikrant Jain
Affiliation:
- Department of Chemistry, Madhyanchal Professional University, Ratibad, Bhopal,India
Keywords:
Natural products, coumarin, antimicrobial, anticoagulant, anti-inflammatory, anticancer drugs, bladder cancer,
lung cancer, breast cancer.
Abstract: Coumarins, a natural class of compounds, firstly isolated from Tonka beans, are found
in various medicinal herbs. This class of compounds has been reported of remarkable biological
and pharmacological applications, including antimicrobial, anticoagulants, anti-inflammatory as
well as cancer. Additionally, coumarins have revealed significant inhibition of different human cancers
viz bladder cancer, lung cancer, prostate cancer, ovarian cancer, colon cancer, breast cancer,
gastric cancer, leukemia, pancreatic cancer, etc. Therefore, the compilation of medicinal research
progress of natural coumarin and its derivatives will be beneficial for scientists and researchers
worldwide. The literature review of medicinal research progress of natural coumarin and its derivatives
was collected from various databases, including PubMed, Web of Science and Science Direct
from the year 1942 to date. The presented data on medicinal research progress of natural coumarin
and its derivatives provides a detailed review which could serve as a platform for future research.
The data presented the medicinal and biological activities of coumarin and its derivatives
like antimicrobial, anticoagulant, anti-inflammatory and anticancer in particular. This could be utilized
for future formulation and development of drugs and references based on coumarin and its
derivatives.
