Title:Deciphering Role of Cytokines for Therapeutic Strategies Against Rheumatoid Arthritis
Volume: 22
Issue: 7
Author(s): Gaurav Doshi*Ami Thakkar
Affiliation:
- Department of Pharmacology, SVKM’s Dr Bhanuben Nanavati College of Pharmacy, V. M. Road, Vile Parle (W), Mumbai, Maharashtra,India
Keywords:
Rheumatoid arthritis, cytokines, interleukins, TNF-α, IL-1, IL-17.
Abstract: Rheumatoid Arthritis (RA) is a systemic, chronic, autoimmune, inflammatory disorder
that affects both large and small synovial joints in a symmetric pattern. RA initiates as painful inflammation
of the joints leading to stiffness of joint, joint destruction and further worsens the condition
causing permanent irreversible damage to the joints, making them physically disabled. Across
the globe, there are around 1.2 million cases of RA reported. Inspite of various available therapeutic
and pharmacological agents against RA, none of the treatments assure complete cure. Understanding
the in depth-role of cytokines and interleukins in the disease pathogenesis of RA could
help in exploiting them for developing novel therapeutic strategies against RA. This review provides
insights into the pathogenesis of RA and gives a brief overview of cytokines, which play an
important role in the progression of the disease. We have also discussed the possible role of interleukins
in the context of RA, which could help future researchers to explore them for identifying
new therapeutic agents.
