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Current HIV Research

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ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

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Case Report

The Identification of A Novel HIV-1 Second-Generation Recombinant form (CRF01_AE/CRF07_BC) Among Men Who Have Sex with Men in Jiangsu, China

Author(s): Yin Yueqi, Zhou Ying, Lu Jing, Guo Hongxiong, Chen Jianshuang, Xuan Yan, Cheng Hao, Yuan Defu, Hu Haiyang, Xu Xiaoqin, Wang Bei* and Fu Gengfeng*

Volume 19, Issue 2, 2021

Published on: 26 October, 2020

Page: [188 - 194] Pages: 7

DOI: 10.2174/1570162X18666201026143200

Price: $65

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Abstract

Background: CRF01_AE and CRF07_BC are the two major HIV-1 virus strains circulating in China. The proportion of dominant subtypes (CRF01_AE and CRF07_BC) among MSM in Jiangsu province was over 80%. A large number of URFs have been found in China in recent years.

Objective: This study aimed to report on novel HIV-1 recombinants.

Methods: We constructed Phylogenetic trees using the maximum likelihood (ML) method with 1000 bootstrap replicates in IQ-TREE 1.6.8 software and determined recombination breakpoints using SimPlot 3.5.1.

Results: We identified a novel, second-generation HIV-1 recombinant (JS020202) between CRF01_ AE and CRF07_BC. The analysis of near full-length genome (NFLG) showed there were at least 8 breakpoints in the virus, which differed from any previously identified CRF and URF around the world.

Conclusion: Novel diverse CRF01_AE/07_BC suggested the complexity trends of HIV-1 genetics. The emergency situation of diverse recombinant strains should be monitored continuously.

Keywords: HIV-1, recombinant, MSM, near full-length genome, URF, CRF.

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