Title:Inhibition of Virulence Factors and Biofilm Formation of Acinetobacter Baumannii by Naturally-derived and Synthetic Drugs
Volume: 22
Issue: 7
Author(s): Nilushi Indika Bamunuarachchi, Fazlurrahman Khan and Young-Mog Kim*
Affiliation:
- Department of Food Science and Technology, Pukyong National University, Busan 48513,South Korea
Keywords:
Acinetobacter baumannii, anti-biofilm, antivirulence, compounds, multiple drug-resistant, synthetic.
Abstract: Acinetobacter baumannii is a gram-negative, aerobic, non-motile, and pleomorphic bacillus.
A. baumannii is also a highly-infectious pathogen causing high mortality and morbidity rates
in intensive care units. The discovery of novel agents against A. baumannii infections is urgently
needed due to the emergence of drug-resistant A. baumannii strains and the limited number of efficacious
antibiotics available for treatment. In addition to the production of several virulence factors,
A. baumannii forms biofilms on the host cell surface as well. Formation of biofilms occurs
through initial surface attachment, microcolony formation, biofilm maturation, and detachment
stages, and is one of the major drug resistance mechanisms employed by A. baumannii. Several
studies have previously reported the efficacy of naturally-derived and synthetic compounds as anti-
biofilm and anti-virulence agents against A. baumannii. Here, inhibition of biofilm formation
and virulence factors of A. baumannii using naturally-derived and synthetic compounds are reviewed.
