Title:Herbal Drug Interaction: Mechanistic Details through Pharmacokinetic Portfolio
Volume: 20
Issue: 8
Author(s): Salman Ahmed, Haroon Khan*, Hamed Mirzaei, Muhammad Mohtasheemul Hasan, Mohamed Eddouks and Maria Daglia*
Affiliation:
- Department of Pharmacy, Abdul Wali Khan University, Mardan 23200,Pakistan
- Department of Pharmacy, University of Naples Federico II Via Domenico Montesano 49, Naples 80131,Italy
Keywords:
Herbal medicine, drug interactions, pharmacokinetic mechanisms, active compounds, enzymatic frameworks, drug
absorption.
Abstract:
Background: A large number of individuals today use herbs as a drug alongside
medicine and non-physician recommended medications, as herbs are thought to be natural and
safe. However, there are many herbs that can potentially interact with other drugs, causing hazardous
effects and/or diminished therapeutic effects of other prescriptions.
Objective: It is ought to be comprehended that herbal drugs contain multiple active compounds in
different percentages, which can change the enzymatic frameworks, transporters, and, additionally,
the physiological processes.
Methods: Different search engines, such as Google Scholar, Scopus, and ScienceDirect, were used
for the search of the data on the subject: pharmacokinetic drug interactions with the herbal products.
Results: This worldwide increment in herbal drug popularity has risen with respect to HDIs. These
PD or PK interactions are particularly significant for medications. Assessment of herbal drug interaction
is difficult because of inconsistency in herbal drug composition and frequently meager information
of active constituent pharmacokinetic. These restrictions are bewildered further by the differing
points of view concerning herbal product regulation.
Conclusion: It is concluded that a basic assessment of certain pharmacokinetic HDI is needed to
settle on educated choices in regard to patient safety. The expanding comprehension of HDPKI
will direct more attention to potential interactions.
