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Current Pharmaceutical Biotechnology

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ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

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Review Article

Biologically Active Antimicrobial Compounds from Marine Microorganisms (2005-2019)

Author(s): Krishna Muddukrishnaiah, K. Akilandeswari*, Sunnapu Prasad and V.P. Shilpa

Volume 22, Issue 8, 2021

Published on: 29 September, 2020

Page: [1046 - 1060] Pages: 15

DOI: 10.2174/1389201021666200929123040

Price: $65

Abstract

Introduction: The increase in contagious diseases like nosocomial infections, urinary tract infections, and meningitis has led to the emergence of antimicrobial resistance urgently needs new antimicrobial medication with new modes of action. Some of the antibiotics present in the market have been obtained from terrestrial plants, or extracted semisynthetically from materials which can be fermented.

Methods: Marine microorganisms account for approximately 80% of sea biomass. They are essential for the survival and well-being of aquatic habitats due to their indispensable contribution to biogeochemical cycles and biological processes. In marine ecosystems, microorganisms live as microbial communities in seawater, where symbiotic relationships are formed, and their ecological functions are fulfilled.

Results: Marine microorganisms remain the largest, most diverse and most exciting source of structurally and functionally complex antimicrobial agents. They are extremely involved in their structure and functions. Enormous biological wealth lies in marine habitats. These microorganisms are potential sources of novel antimicrobial compounds to combat the most infectious diseases like nosocomial infections, and urinary tract infections.

Conclusion: This study deals with biologically active antimicrobial compounds taken from marine microorganism source, which was reported between the years 2005 and 2019. This review highlights their chemical groups, their bioactivities and sources. Marine microorganism exploitation techniques have also been reported by the authors.

Keywords: Antimicrobial-resistant, marine environment, marine bacteria, marine fungi, antimicrobial agents, biogeochemical cycles.

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[1]
https://www.cdc.gov/drugresistance/index.html
[2]
Schinke, C.; Martins, T.; Queiroz, S.C.N.; Melo, I.S.; Reyes, F.G.R. Antibacterial compounds from marine bacteria, 2010-2015. J. Nat. Prod., 2017, 80(4), 1215-1228.
[PMID: 28362500]
[3]
Subramani, R.; Sipkema, D. marine rare actinomycetes: A promising source of structurally diverse and unique novel natural products. Mar. Drugs, 2019, 17, 5249.
[4]
Kashfi, R.; Kelsey, C.; Gang, D.J.; Call, D.R.; Gang, D.R. Metabolomic diversity and identification of antibacterial activities of bacteria isolated from marine sediments in Hawai’i and Puerto Rico. Front. Mol. Biosci., 2020, 7, 23.
[http://dx.doi.org/10.3389/fmolb.2020.00023] [PMID: 32158766]
[5]
Chaib De Mares, M.; Sipkema, D.; Huang, S.; Bunk, B.; Overmann, J.; van Elsas, J.D. Host specificity for bacterial, archaeal and fungal communities determined for high- and low-microbial abundance sponge species in two genera. Front. Microbiol., 2017, 8, 2560.
[http://dx.doi.org/10.3389/fmicb.2017.02560] [PMID: 29326681]
[6]
Tortorella, E.; Tedesco, P.; Palma Esposito, F.; January, G.G.; Fani, R.; Jaspars, M.; de Pascale, D. Antibiotics from deep-sea microorganisms: Current discoveries and perspectives. Mar. Drugs, 2018, 16(10), 1-16.
[PMID: 30274274]
[7]
Goodfellow, M.; Fiedler, H.P. A guide to successful bioprospecting: informed by actinobacterial systematics. Antonie van Leeuwenhoek, 2010, 98(2), 119-142.
[PMID: 20582471]
[8]
Dunne, W.M., Jr Bacterial adhesion: Seen any good biofilms lately? Clin. Microbiol. Rev., 2002, 15(2), 155-166.
[PMID: 11932228]
[9]
Egan, S.; Thomas, T.; Kjelleberg, S. Unlocking the diversity and biotechnological potential of marine surface associated microbial communities. Curr. Opin. Microbiol., 2008, 11(3), 219-225.
[PMID: 18524668]
[10]
Montalvo, N.F.; Hill, R.T. Sponge-associated bacteria are strictly maintained in two closely related but geographically distant sponge hosts. Appl. Environ. Microbiol., 2011, 77(20), 7207-7216.
[http://dx.doi.org/10.1128/AEM.05285-11] [PMID: 21856832]
[11]
Taylor, M.W.; Schupp, P.J.; Dahllöf, I.; Kjelleberg, S.; Steinberg, P.D. Host specificity in marine sponge-associated bacteria, and potential implications for marine microbial diversity. Environ. Microbiol., 2004, 6(2), 121-130.
[PMID: 14756877]
[12]
Wilson, G.S.; Raftos, D.A.; Nair, S.V. Antimicrobial activity of surface attached marine bacteria in biofilms. Microbiol. Res., 2011, 166(6), 437-448.
[http://dx.doi.org/10.1016/j.micres.2010.08.003] [PMID: 20869859]
[13]
De Voogd, N.J.; Gauvin‐Bialecki, A.; Polónia, A.R.M.; Cleary, D.F.R. Assessing the bacterial communities of sponges inhabiting the remote western Indian Ocean island of Mayotte. Mar. Ecol. (Berl.), 2018, 39, e12517.
[http://dx.doi.org/10.1111/maec.12517]
[14]
Rohwer, F.; Seguritan, V.; Azam, F.; Knowlton, N. Diversity and distribution of coral associated bacteria. Mar. Ecol. Prog. Ser., 2002, 243, 1-10.
[15]
Soria-Mercado, I.E.; Prieto-Davo, A.; Jensen, P.R.; Fenical, W. Antibiotic terpenoid chloro-dihydroquinones from a new marine actinomycete. J. Nat. Prod., 2005, 68(6), 904-910.
[PMID: 15974616]
[16]
Macherla, V.R.; Liu, J.; Bellows, C.; Teisan, S.; Nicholson, B.; Lam, K.S.; Potts, B.C.; Glaciapyrroles, A. B, and C, pyrrolosesquiterpenes from a Streptomyces sp. isolated from an Alaskan marine sediment. J. Nat. Prod., 2005, 68(5), 780-783.
[PMID: 15921430]
[17]
Bruntner, C.; Binder, T.; Pathom-aree, W.; Goodfellow, M.; Bull, A.T.; Potterat, O.; Puder, C.; Hörer, S.; Schmid, A.; Bolek, W.; Wagner, K.; Mihm, G.; Fiedler, H.P. Frigocyclinone, a novel angucyclinone antibiotic produced by a Streptomyces griseus strain from Antarctica. J. Antibiot. (Tokyo), 2005, 58(5), 346-349.
[PMID: 16060387]
[18]
Manam, R.R.; Teisan, S.; White, D.J.; Nicholson, B.; Grodberg, J.; Neuteboom, S.T.C.; Lam, K.S.; Mosca, D.A.; Lloyd, G.K.; Potts, B.C. Lajollamycin, a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic from the marine actinomycete Streptomyces nodosus. J. Nat. Prod., 2005, 68(2), 240-243.
[PMID: 15730252]
[19]
Gorajana, A.; Kurada, B.V.; Peela, S.; Jangam, P.; Vinjamuri, S.; Poluri, E.; Zeeck, A. 1-Hydroxy-1-norresistomycin, a new cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN1/7. J. Antibiot. (Tokyo), 2005, 58(8), 526-529.
[PMID: 16266126]
[20]
Kock, I.; Maskey, R.P.; Biabani, M.A.; Helmke, E.; Laatsch, H. 1-Hydroxy-1-norresistomycin and resistoflavin methyl ether: New antibiotics from marine-derived streptomycetes. J. Antibiot. (Tokyo), 2005, 58(8), 530-534.
[PMID: 16266127]
[21]
Kwon, H.C.; Kauffman, C.A.; Jensen, P.R.; Fenical, W. Marinomycins A-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus “marinispora”. J. Am. Chem. Soc., 2006, 128(5), 1622-1632.
[PMID: 16448135]
[22]
Asolkar, R.N.; Jensen, P.R.; Kauffman, C.A.; Fenical, W. Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085. J. Nat. Prod., 2006, 69(12), 1756-1759.
[PMID: 17190455]
[23]
Socha, A.M.; LaPlante, K.L.; Rowley, D.C. New bisanthraquinone antibiotics and semi-synthetic derivatives with potent activity against clinical Staphylococcus aureus and Enterococcus faecium isolates. Bioorg. Med. Chem., 2006, 14(24), 8446-8454.
[PMID: 16979896]
[24]
Jensen, P.R.; Williams, P.G.; Oh, D.C.; Zeigler, L.; Fenical, W. Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora. Appl. Environ. Microbiol., 2007, 73(4), 1146-1152.
[PMID: 17158611]
[25]
Desjardine, K.; Pereira, A.; Wright, H.; Matainaho, T.; Kelly, M.; Andersen, R.J. Tauramamide, a lipopeptide antibiotic produced in culture by Brevibacillus laterosporus isolated from a marine habitat: Structure elucidation and synthesis. J. Nat. Prod., 2007, 70(12), 1850-1853.
[PMID: 18044840]
[26]
Oh, D.C.; Gontang, E.A.; Kauffman, C.A.; Jensen, P.R.; Fenical, W. Salinipyrones and pacificanones, mixed-precursor polyketides from the marine actinomycete Salinispora pacifica. J. Nat. Prod., 2008, 71(4), 570-575.
[PMID: 18321059]
[27]
Fiedler, H.P.; Bruntner, C.; Riedlinger, J.; Bull, A.T.; Knutsen, G.; Goodfellow, M.; Jones, A.; Maldonado, L.; Pathom-aree, W.; Beil, W.; Schneider, K.; Keller, S.; Sussmuth, R.D.; Proximicin, A. B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora. J. Antibiot. (Tokyo), 2008, 61(3), 158-163.
[PMID: 18503194]
[28]
Oku, N.; Kawabata, K.; Adachi, K.; Katsuta, A.; Shizuri, Y. Unnarmicins A and C, new antibacterial depsipeptides produced by marine bacterium Photobacterium sp. MBIC06485. J. Antibiot. (Tokyo), 2008, 61(1), 11-17.
[PMID: 18305354]
[29]
Oku, N.; Adachi, K.; Matsuda, S.; Kasai, H.; Takatsuki, A.; Shizuri, Y. Ariakemicins A and B, novel polyketide-peptide antibiotics from a marine gliding bacterium of the genus Rapidithrix. Org. Lett., 2008, 10(12), 2481-2484.
[PMID: 18498148]
[30]
Hohmann, C.; Schneider, K.; Bruntner, C.; Irran, E.; Nicholson, G.; Bull, A.T.; Jones, A.L.; Brown, R.; Stach, J.E.; Goodfellow, M.; Beil, W.; Krämer, M.; Imhoff, J.F.; Süssmuth, R.D.; Fiedler, H.P. Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937. J. Antibiot. (Tokyo), 2009, 62(2), 99-104.
[PMID: 19198633]
[31]
Carlson, J.C.; Li, S.; Burr, D.A.; Sherman, D.H. Isolation and characterization of tirandamycins from a marine-derived Streptomyces sp. J. Nat. Prod., 2009, 72(11), 2076-2079.
[PMID: 19883065]
[32]
Arumugam, M.; Mitra, A.; Jaisankar, P.; Dasgupta, S.; Sen, T.; Gachhui, R.; Kumar Mukhopadhyay, U.; Mukherjee, J. Isolation of an unusual metabolite 2-allyloxyphenol from a marine actinobacterium, its biological activities and applications. Appl. Microbiol. Biotechnol., 2010, 86(1), 109-117.
[PMID: 19902208]
[33]
Pettit, G.R.; Knight, J.C.; Herald, D.L.; Pettit, R.K.; Hogan, F.; Mukku, V.J.; Hamblin, J.S.; Dodson, M.J.; Chapuis, J.C. Antineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris. J. Nat. Prod., 2009, 72(3), 366-371.
[PMID: 19226154]
[34]
Asolkar, R.N.; Kirkland, T.N.; Jensen, P.R.; Fenical, W. Arenimycin, an antibiotic effective against rifampin- and methicillin-resistant Staphylococcus aureus from the marine actinomycete Salinispora arenicola. J. Antibiot. (Tokyo), 2010, 63(1), 37-39.
[PMID: 19927167]
[35]
Rahman, H.; Austin, B.; Mitchell, W.J.; Morris, P.C.; Jamieson, D.J.; Adams, D.R.; Spragg, A.M.; Schweizer, M. Novel anti-infective compounds from marine bacteria. Mar. Drugs, 2010, 8(3), 498-518.
[PMID: 20411112]
[36]
Niu, S.; Li, S.; Chen, Y.; Tian, X.; Zhang, H.; Zhang, G.; Zhang, W.; Yang, X.; Zhang, S.; Ju, J.; Zhang, C. Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127. J. Antibiot. (Tokyo), 2011, 64(11), 711-716.
[PMID: 21897400]
[37]
Zhou, X.; Huang, H.; Chen, Y.; Tan, J.; Song, Y.; Zou, J.; Tian, X.; Hua, Y.; Ju, J. Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652. J. Nat. Prod., 2012, 75(12), 2251-2255.
[PMID: 23215246]
[38]
Cude, W.N.; Mooney, J.; Tavanaei, A.A.; Hadden, M.K.; Frank, A.M.; Gulvik, C.A.; May, A.L.; Buchan, A. Production of the antimicrobial secondary metabolite indigoidine contributes to competitive surface colonization by the marine Roseobacter, Phaeobacter sp. strain Y4I. Appl. Environ. Microbiol., 2012, 78(14), 4771-4780.
[PMID: 22582055]
[39]
Pan, H.Q.; Zhang, S.Y.; Wang, N.; Li, Z.L.; Hua, H.M.; Hu, J.C.; Wang, S.J. New spirotetronate antibiotics, lobophorins H and I, from a South China Sea-derived Streptomyces sp. 12A35. Mar. Drugs, 2013, 11(10), 3891-3901.
[PMID: 24132178]
[40]
Song, Y.; Huang, H.; Chen, Y.; Ding, J.; Zhang, Y.; Sun, A.; Zhang, W.; Ju, J. Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406. J. Nat. Prod., 2013, 76(12), 2263-2268.
[PMID: 24251399]
[41]
Mondol, M.A.; Shin, H.J.; Islam, M.T. Diversity of secondary metabolites from marine Bacillus species: Chemistry and biological activity. Mar. Drugs, 2013, 11(8), 2846-2872.
[PMID: 23941823]
[42]
Zhou, X.; Huang, H.; Li, J.; Song, Y.; Jiang, R.; Liu, J.; Zhang, S.; Hua, Y.; Ju, J. New anti-infective cycloheptadepsipeptide congeners and absolute stereochemistry from the deep sea-derived Streptomyces drozdowiczii SCSIO 10141. Tetrahedron, 2014, 70(42), 7795-7801.
[43]
Song, Y.; Li, Q.; Liu, X.; Chen, Y.; Zhang, Y.; Sun, A.; Zhang, W.; Zhang, J.; Ju, J. Cyclic hexapeptides from the deep South China sea-derived Streptomyces scopuliridis SCSIO ZJ46 active against pathogenic gram-positive bacteria. J. Nat. Prod., 2014, 77(8), 1937-1941.
[PMID: 25072108]
[44]
Kang, H.K.; Seo, C.H.; Park, Y. Marine peptides and their anti-infective activities. Mar. Drugs, 2015, 13(1), 618-654.
[PMID: 25603351]
[45]
Yuan, J.; Zhao, M.; Li, R.; Huang, Q.; Rensing, C.; Raza, W.; Shen, Q. Antibacterial compounds-macrolactin alters the soil bacterial community and abundance of the gene encoding PKS. Front. Microbiol., 2016, 7, 1904.
[PMID: 27965639]
[46]
Agrawal, S.; Acharya, D.; Adholeya, A.; Barrow, C.J.; Deshmukh, S.K. Nonribosomal peptides from marine microbes and their antimicrobial and anticancer potential. Front. Pharmacol., 2017, 8, 828.
[PMID: 29209209]
[47]
Muddukrishnaiah, K.; Shilpa, V.P. Marine anaerobic bacterial diversity for the production of antimicrobial agents. Environ. Dis., 2017, 2, 99-102.
[48]
Raimundo, I.; Silva, S.G.; Costa, R.; Keller-Costa, T. Bioactive secondary metabolites from octocoral-associated microbes-new chances for blue growth. Mar. Drugs, 2018, 16(12), 485.
[PMID: 30518125]
[49]
Srivastava, A.; Mishra, V. Marine peptides act as novel chemotherapeutic agent. J. Microbiol. Exp., 2018, 6, 267-270.
[50]
Schieferdecker, S.; Shabuer, G.; Knuepfer, U.; Hertweck, C. Clostrindolin is an antimycobacterial pyrone alkaloid from Clostridium beijerinckii. Org. Biomol. Chem., 2019, 17(25), 6119-6121.
[PMID: 31168541]
[51]
Molinski, T.F.; Dalisay, D.S.; Lievens, S.L.; Saludes, J.P. Drug development from marine natural products. Nat. Rev. Drug Discov., 2009, 8(1), 69-85.
[PMID: 19096380]
[52]
Butler, M.S.; Robertson, A.A.; Cooper, M.A. Natural product and natural product derived drugs in clinical trials. Nat. Prod. Rep., 2014, 31(11), 1612-1661.
[PMID: 25204227]
[53]
Bhadury, P.; Mohammad, B.T.; Wright, P.C. The current status of natural products from marine fungi and their potential as anti-infective agents. J. Ind. Microbiol. Biotechnol., 2006, 33(5), 325-337.
[PMID: 16429315]
[54]
Simon, C.; Daniel, R. Metagenomic analyses: Past and future trends. Appl. Environ. Microbiol., 2011, 77(4), 1153-1161.
[PMID: 21169428]
[55]
Gomes, N.G.; Lefranc, F.; Kijjoa, A.; Kiss, R. Can some marine-derived fungal metabolites become actual anticancer agents? Mar. Drugs, 2015, 13(6), 3950-3991.
[PMID: 26090846]
[56]
Fredimoses, M.; Zhou, X.; Lin, X.; Tian, X.; Ai, W.; Wang, J.; Liao, S.; Liu, J.; Yang, B.; Yang, X.; Liu, Y. New prenylxanthones from the deep-sea derived fungus Emericella sp. SCSIO 05240. Mar. Drugs, 2014, 12(6), 3190-3202.
[PMID: 24879543]
[57]
Yao, Q.; Wang, J.; Zhang, X.; Nong, X.; Xu, X.; Qi, S. Cytotoxic polyketides from the deep-sea-derived fungus Engyodontium album DFFSCS021. Mar. Drugs, 2014, 12(12), 5902-5915.
[PMID: 25501793]
[58]
Niu, S.; Liu, D.; Hu, X.; Proksch, P.; Shao, Z.; Lin, W. Spiromastixones A-O, antibacterial chlorodepsidones from a deep-sea-derived Spiromastix sp. fungus. J. Nat. Prod., 2014, 77(4), 1021-1030.
[PMID: 24571273]
[59]
Guo, W.; Zhang, Z.; Zhu, T.; Gu, Q.; Li, D. Penicyclones A-E, Antibacterial polyketides from the deep-sea-derived fungus Penicillium sp. F23-2. J. Nat. Prod., 2015, 78(11), 2699-2703.
[PMID: 26540093]
[60]
Farha, A.K.; Hatha, A.M. Bioprospecting potential and secondary metabolite profile of a novel sediment-derived fungus Penicillium sp. ArCSPf from continental slope of Eastern Arabian Sea. Mycology, 2019, 10(2), 109-117.
[PMID: 31069124]
[61]
Zobell, C.E.; Morita, R.Y. Barophilic bacteria in some deep sea sediments. J. Bacteriol., 1957, 73(4), 563-568.
[PMID: 13428691]
[62]
Eloe, E.A.; Malfatti, F.; Gutierrez, J.; Hardy, K.; Schmidt, W.E.; Pogliano, K.; Pogliano, J.; Azam, F.; Bartlett, D.H. Isolation and characterization of a psychropiezophilic alphaproteobacterium. Appl. Environ. Microbiol., 2011, 77(22), 8145-8153.
[PMID: 21948832]
[63]
Takai, K.; Miyazaki, M.; Hirayama, H.; Nakagawa, S.; Querellou, J.; Godfroy, A. Isolation and physiological characterization of two novel, piezophilic, thermophilic chemolithoautotrophs from a deep-sea hydrothermal vent chimney. Environ. Microbiol., 2009, 11(8), 1983-1997.
[PMID: 19689705]
[64]
Aoki, M.; Ehara, M.; Saito, Y.; Yoshioka, H.; Miyazaki, M.; Saito, Y.; Miyashita, A.; Kawakami, S.; Yamaguchi, T.; Ohashi, A.; Nunoura, T.; Takai, K.; Imachi, H. A long-term cultivation of an anaerobic methane-oxidizing microbial community from deep-sea methane-seep sediment using a continuous-flow bioreactor. PLoS One, 2014, 9(8), e105356.
[PMID: 25141130]
[65]
Landreau, M.; Duthoit, F.; Roussel, E.; Schönherr, S.; Georges, M.; Godfroy, A.; Le Blay, G. Cultivation of an immobilized (hyper)thermophilic marine microbial community in a bioreactor. FEMS Microbiol. Lett., 2016, 363(17), 1-7.
[PMID: 27528693]
[66]
Lever, M.A.; Rogers, K.L.; Lloyd, K.G.; Overmann, J.; Schink, B.; Thauer, R.K.; Hoehler, T.M.; Jørgensen, B.B. Life under extreme energy limitation: A synthesis of laboratory- and field-based investigations. FEMS Microbiol. Rev., 2015, 39(5), 688-728.
[PMID: 25994609]
[67]
Bond, T.; Templeton, M.R. History and future of domestic biogas plants in the developing world. Energy Sustain. Dev., 2011, 15, 347-354.
[68]
Rumpel, C.; Kögel-Knabner, I. Deep soil organic matter-a key but poorly understood component of terrestrial C cycle. Plant Soil, 2011, 338, 143-158.
[69]
Schmidt, M.W.I.; Torn, M.S.; Abiven, S.; Dittmar, T.; Guggenberger, G.; Janssens, I.A.; Kleber, M.; Kögel-Knabner, I.; Lehmann, J.; Manning, D.A.C.; Nannipieri, P.; Rasse, D.P.; Weiner, S.; Trumbore, S.E. Persistence of soil organic matter as an ecosystem property. Nature, 2011, 478(7367), 49-56.
[PMID: 21979045]
[70]
Barone, R.; De Santi, C.; Palma Esposito, F.; Tedesco, P.; Galati, F.; Visone, M.; Di Scala, A.; de Pascale, D. Marine metagenomics, a valuable tool for enzymes and bioactive compounds discovery. Front. Mar. Sci., 2014, 1, 1-6.
[71]
Zhang, W.; Liu, Z.; Li, S.; Yang, T.; Zhang, Q.; Ma, L.; Tian, X.; Zhang, H.; Huang, C.; Zhang, S.; Ju, J.; Shen, Y.; Zhang, C. Spiroindimicins A-D: New bisindole alkaloids from a deep-sea-derived actinomycete. Org. Lett., 2012, 14(13), 3364-3367.
[PMID: 22694269]
[72]
Tangherlini, M.; Dell’Anno, A.; Zeigler Allen, L.; Riccioni, G.; Corinaldesi, C. Assessing viral taxonomic composition in benthic marine ecosystems: Reliability and efficiency of different bioinformatic tools for viral metagenomic analyses. Sci. Rep., 2016, 6, 28428.
[PMID: 27329207]
[73]
Verma, P.; Raghavan, R.V.; Jeon, C.O.; Lee, H.J.; Priya, P.V.; Dharani, G.; Kirubagaran, R. Complex bacterial communities in the deep-sea sediments of the Bay of Bengal and volcanic Barren Island in the Andaman Sea. Mar. Genomics, 2017, 31, 33-41.
[PMID: 27570125]
[74]
Gomez-Escribano, J.P.; Alt, S.; Bibb, M.J. Next generation sequencing of actinobacteria for the discovery of novel natural products. Mar. Drugs, 2016, 14(4), 78.
[PMID: 27089350]

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