Title:FADS1 is a Prognostic Biomarker in Bladder Cancer: A Study Based on TCGA Data
Volume: 24
Issue: 8
Author(s): Ying Lu, Jing Shao, Xu Shu*, Yaofei Jiang, Jianfang Rong, Yongkang Lai and Ji Liu
Affiliation:
- Department of Gastroenterology, First Affiliated Hospital of Nanchang University, NO. 17 Yongwaizheng Street, Nanchang 330006, Jiangxi Province,China
Keywords:
FADS1, bladder cancer, poor prognosis, biomarker, TCGA, survival.
Abstract:
Aim and Objective: Fatty acid desaturase 1 (FADS1) has been reported to be a potential
biomarker in various cancers. However, no study has explored the relationship between FADS1 expression
and bladder cancer. Our study aimed to investigate the role of FADS1 in bladder cancer
prognosis via The Cancer Genome Atlas (TCGA).
Materials and Methods: RNA-Seq expression of 414 tumor tissues and 19 paired normal tissues,
as well as corresponding clinical data, were downloaded from the TCGA database. Two cancer cases
were excluded due to a lack of clinical information. The association between FADS1 and the
clinicopathological features of bladder cancer was analyzed. This study was conducted in October
2019 in China.
Results: The high expression of FADS1 in bladder cancer was significantly related to histological
grade (OR = 0.155 for low vs. high), clinical stage (OR=2.074 for III or IV vs. I or II), T classification
(OR=2.326 for T3 or T4 vs. T1 or T2), lymphatic metastasis (OR=1.923 for N1 or N2 or N3
vs. N0) and distant metastasis (OR=4.883 for yes vs. no) (all p-values <0.05). Bladder cancer with
high FADS1 levels was related to a worse prognosis than bladder cancer with low FADS1 levels
(p= 1.626*10-5), according to median expression value 3.622. FADS1 was an independent factor of
overall survival in bladder cancer, with a hazard ratio of 1.048 (95%CI: 1.020–1.077, p = 0.001).
Conclusion: Increased FADS1 expression in bladder cancer is associated with advanced clinicopathological
features and may be a potential biomarker for poor prognosis.
