Title:Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase Pathways
Volume: 19
Issue: 6
Author(s): Aisha Siddiqui, Sayeed Akhtar*, Zahoor Shah, Iekhsan Othman and Yatinesh Kumari*
Affiliation:
- Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha-21974,Saudi Arabia
- Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, 47500 Selangor,Malaysia
Keywords:
Alzheimer's Diseases, 5-lipoxygenase, Neuro Inflammation, Neurodegeneration, Lipid Molecule, Arachidonic
Acid.
Abstract: It is a known fact that inflammation affects several physiological processes, including
the functioning of the central nervous system. Additionally, impairment of lipid mechanisms/pathways
have been associated with a number of neurodegenerative disorders and Alzheimer’s Disease
(AD) is one of them. However, much attention has been given to the link between tau and beta-
amyloid hypothesis in AD pathogenesis/prognosis. Increasing evidences suggest that biologically
active lipid molecules could influence the pathophysiology of AD via a different mechanism of
inflammation. This review intends to highlight the role of inflammatory responses in the context of
AD with the emphasis on biochemical pathways of lipid metabolism enzyme, 5-lipoxygenase (5-
LO).
