Title:An Intimate Alliance of DNA-Damage Response Network with Cell-Cycle Checkpoints Amid Events of Uncontrolled Cellular Proliferation: A Mini- Review
Volume: 21
Issue: 9
Author(s): Aroni Chatterjee, Keshav Rajarshi, Rajni Khan, Hiya Ghosh, Sonia Kapoor*Shashikant Ray *
Affiliation:
- Amity Institute of Molecular Medicine and Stem Cell Research Amity University, Noida,India
- Department of Biotech, Mahatma Gandhi Central University, Motihari 845401, Bihar,India
Keywords:
Cancer, cell cycle, checkpoint, DNA damage, oncogene, tumor suppressor.
Abstract: There is close interdependence between cell survival, cell senescence, events of the cell
cycle, apoptosis, malignancy development, and tumor responses to cancer treatment. Intensive
studies and elaborate researches have been conducted on the functional aspects of oncogenes, tumor
suppressor genes, apoptotic genes, and members guiding cell cycle regulation. These disquisitions
have put forward the existence of a highly organized response pathway termed as a DNA-damage
response network. The pathways detecting DNA damage and signaling are intensively linked
to the events of cell-cycle arrest, cell proliferation, apoptosis, and cell senescence. DNA damage responses
are complex systems that incorporate specific “sensor” and “transducer” proteins, for assessment
of damage and signal transmission, respectively. These signals are thereafter relayed upon
various “effector” proteins involved in different cellular pathways. It may include those governing
cell-cycle checkpoints, participating in DNA repair, cell senescence, and apoptosis. This review
discusses the role of the tumour suppressor gene, oncogenes, cell cycle checkpoint regulators
during DNA damage response and regulation.
