Title:MicroRNA Expression Levels in Patients with Hashimoto Thyroiditis: A Single Centre Study
Volume: 21
Issue: 6
Author(s): Hale O. Yilmaz*, Alper H. Cebi, Mustafa Kocak, Halil O. Ersoz and Mevlit Ikbal
Affiliation:
- Department of Medical Genetics, Faculty of Medicine, Karadeniz Technical University, Trabzon,Turkey
Keywords:
Circulatory miRNA, Hashimoto thyroiditis, miR-451, miR-375, miR-22, autoimmune condition.
Abstract:
Objective: To determine the circulatory miRNA expression levels in patients with Hashimoto
thyroiditis (HT) at the time of diagnosis and follow-up period compared with healthy controls.
Methods: We collected blood samples from 34 patients with HT (4 males and 30 females) at the
time of first diagnosis (Group P) and euthyroid period (Group E). Thirty-three healthy controls
(Group H) blood samples were also included in the study. Expression levels of five different circulating
miRNAs (miR-22, miR-141, miR-155, miR-375, miR-451) were evaluated using real-time
polymerase chain reaction.
Results: There was a significant difference in miR-375 levels between the groups P and H. Also,
for miR-451, there was a significant difference between the P and E groups. Finally, there was a
moderate positive correlation between thyroid-stimulating hormone values and miR-22 expression
levels for the P group.
Conclusion: miRNAs have important roles at all stages of the diseases. More studies must be performed
in all thyroid diseases and autoimmune diseases, including HT.
