Title:Resveratrol, a Molecule with Anti-Inflammatory and Anti-Cancer Activities: Natural Product to Chemical Synthesis
Volume: 28
Issue: 19
Author(s): Sunil Kumar, Yu-Chia Chang, Kuei-Hung Lai and Tsong-Long Hwang*
Affiliation:
- Research Center for Chinese Herbal Medicine, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303,Taiwan
Keywords:
Resveratrol, natural product, chemical synthesis, anti-cancer activity, anti-inflammatory activity, structure
activity relationship (SAR).
Abstract:
Background: Resveratrol, a natural polyphenol product, is used in plant defense
from fungal and microbial aggression. It is found naturally, especially in plants such as
grapes, peanuts, and berries. It has the highest concentrations in blueberries, mulberries,
blackberries, and the skin of red grapes. Resveratrol has various pharmacological properties
such as anti-inflammatory, cytoprotective, and antineoplastic activities.
Methods: We conducted a literature survey using standard tools such as Google, Reaxys, Scifinder,
Scihub, and patent Espacenet to compile the biosynthetic pathways, all organic synthetic
methods, and biological activities reported for resveratrol till date.
Results: More than one hundred research articles and patents were referred to write this review.
About twenty-five of them are related to chemical synthesis, and the rests are about the
source, pharmacological activity, and other properties of resveratrol. This study reveals that
many common pathways are involved in various pharmacological activities, which can be
useful for treating various diseases based on the pathways involved. Reactions such as
Pfitzner-Moffatt oxidation, Wittig-Horner condensation, Mizoroki–Heck, Perkin, Wittig, etc.
have been used in resveratrol synthesis. A structure-activity relationship was also established
based on its analogs and derivatives.
Conclusion: This review examined and reported all the published biological activities and
chemical syntheses of resveratrol apart from the biosynthetic pathway. Due to its valuable
biological activities, various synthetic approaches have been reported till date. The reported
synthetic operations are suitable for large-scale industrial production. Moreover, these comprehensive
synthetic procedures could be utilized in the preparation of stilbenes and other related
compounds in future endeavors.
