Title:Synthesis, Antimicrobial Evaluation and Docking Study of Novel Thiosemicarbazone Clubbed with 1,2,3-Triazoles
Volume: 17
Issue: 6
Author(s): Adinath D. Badar, Shubham M. Sulakhe, Mahesh B. Muluk, Naziya N. M. A. Rehman, Prashant P. Dixit, Prafulla B. Choudhari, Giribala M. Bondle and Kishan P. Haval*
Affiliation:
- Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University SubCampus, Osmanabad 413501,India
Keywords:
1, 2, 3-triazole, thiosemicarbazone, antimicrobial Activity, molecular Docking Study, click Chemistry.
Abstract:
Background: Thiosemicarbazone, 1,2,3-triazole and their derivatives received great
pharmaceutical importance due to their prominent biological activities. In the present study, the
molecular hybrid thiosemicarbazone-1,2,3-triazoles derivatives were synthesized and screened for
their antimicrobial activities.
Methods: A series of thiosemicarbazone clubbed with 1,2,3-triazole derivatives were synthesized
via click chemistry approach in good yields. The structures of synthesized compounds were assigned
by their spectral data. The in vitro antimicrobial activity was performed by the agar well diffusion
method. A molecular docking study was performed to identify the possible mode of action
of synthesized derivatives.
Results: The compounds 5d, 5h, 5i and 5k exhibited excellent antimicrobial activities against both
antibacterial and antifungal pathogens. The active thiosemicarbazone-1,2,3-triazole derivatives
showed excellent binding affinity towards DNA gyrase.
Conclusion: The molecular hybrid thiosemicarbazone-1,2,3-triazole derivatives were synthesized.
The newly synthesized compounds were evaluated for their antimicrobial activities. Few of the
thiosemicarbazone-1,2,3-triazoles derivatives have exhibited good antimicrobial activities. They
have shown excellent binding affinity towards DNA gyrase.
