Title:Melatonin Could Be Beneficial in SARS-CoV-2 Therapy
Volume: 11
Issue: 5
Author(s): Sanaz Baghban Rahimi and Ahmad Hosseinzadeh Adli*
Affiliation:
- Department of Microbiology, Tabriz University of Medical Sciences, Tabriz,Iran
Keywords:
Melatonin, SARS-CoV-2, treatment, anti-inflammatory, immunomodulator, natural.
Abstract: Novel coronavirus (SARS-CoV-2) can infect the respiratory tract and cause severe respiratory
syndrome. The excessive inflammatory response is involved in the pathogenicity of the
SARS-CoV-2. Symptoms of SARS-CoV-2 are generally associated with immunopathogenesis and
may result in pulmonary tissue damage. Melatonin is a natural and multifunctional hormone that is
involved in both physiological and pathological conditions in the body, such as immune modulation,
anti-inflammation, and antioxidant. Melatonin is found in foods, animal and human milk and
increases the expression of anti-inflammatory cytokines and, as an adjuvant treatment in SARS--
CoV-2 infection, it may have considerable therapeutic potential, because of its safety and immunomodulatory
effects.
