Title:Drug Delivery Nanosystems in Glioblastoma Multiforme Treatment: Current State of the Art
Volume: 19
Issue: 6
Author(s): Leonardo Delello Di Filippo, Jonatas Lobato Duarte, Marcela Tavares Luiz, Jennifer Thayanne Cavalcante de Araújo and Marlus Chorilli *
Affiliation:
- School of Pharmaceutical Sciences, Sao Paulo State University (UNESP),Brazil
Keywords:
Brain cancer, pharmaceutical nanotechnology, cancer therapy, lipid-based systems, polymeric systems, inorganic
nanoparticles.
Abstract: Glioblastoma multiforme (GBM) is the most common primary malignant Central Nervous
System cancer, responsible for about 4% of all deaths associated with neoplasia, characterized
as one of the fatal human cancers. Tumor resection does not possess curative character, thereby
radio and/or chemotherapy are often necessary for the treatment of GBM. However, drugs used
in GBM chemotherapy present some limitations, such as side effects associated with non-specific
drug biodistribution as well as limited bioavailability, which limits their clinical use. To attenuate
the systemic toxicity and overcome the poor bioavailability, a very attractive approach is drug encapsulation
in drug delivery nanosystems. The main focus of this review is to explore the actual
cancer global problem, enunciate barriers to overcome in the pharmacological treatment of GBM,
as well as the most updated drug delivery nanosystems for GBM treatment and how they influence
biopharmaceutical properties of anti-GBM drugs. The discussion will approach lipid-based and polymeric
nanosystems, as well as inorganic nanoparticles, regarding their technical aspects as well
as biological effects in GBM treatment. Furthermore, the current state of the art, challenges to overcome
and future perspectives in GBM treatment will be discussed.
