Title:The Role of Skin and Gut Microbiome and Epigenetic Modifications in Skin-Autoimmune Disorders
Volume: 21
Issue: 4
Author(s): Giuseppe Murdaca, Monica Greco, Simone Negrini, Marco Casciaro and Sebastiano Gangemi*
Affiliation:
- Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, Messina 98125,Italy
Keywords:
Microbiome, skin, gut flora, autoimmune disorders, miRNAs , fungi.
Abstract: Human microbiota and immune system are strictly connected to each other.
Several studies demonstrated that normal skin and/or gut floral alterations may have
negative consequences on disease pathogenesis. Indeed, a strong association between
skin and gut microbiota alterations and autoimmune diseases was found. Moreover, a
significant interplay between microbiome and miRNAs expression was noticed among
several conditions. The aim of this review article is to shed new light on some of the
commonest skin disorders such as psoriasis, atopic dermatitis, allergic contact
dermatitis, with special regard to epigenetic pathogenetic mechanisms such as miRNAs
expression and skin and gut microbiome alterations. Indeed, evidence is still lacking
regarding these two factors and their possible interactions. We believe their implications
may be crucial for screening, early diagnosis and also therapeutic strategies; therefore,
this field could represent a promising challenge for further studies.
