Title:Current Trends on Hemopoietic Stem Cells
Volume: 16
Issue: 2
Author(s): Chinwe Okeke*, Ufele Silas, Chinedu Okeke and Chiedozie Chikwendu
Affiliation:
- Medical Laboratory Science Department, Faculty of Health Science and Tech. University of Nigeria, Nsukka,Nigeria
Keywords:
Stem cells, haemopoiesis, transplantation, blood, haemopoietic, differentiation.
Abstract: Advances in single-cell technology and genetic mouse models have resulted in the identification
of new types of hemopoietic stem cells (HSC), resulting in baffling observations, suggesting a
reconsideration of the long-held notion that all hematopoietic cells in the adult are derived from HSCs.
The existence of long-lived HSC-independent hematopoiesis has led to the conclusion that despite the
single hierarchical differentiation route that generates functional blood types, other differentiation
routes exist in-vivo. Heterogeneity in the HSC population and the evolving knowledge around HSC has
translated to it’s improved application as a therapeutic tool for various blood disorders. The reprogramming
of non-hematopoietic somatic and mature blood cells to pluripotency with their subsequent
differentiation into hematopoietic stem cells/progenitor cells and the introduction of new generation
sequencing holds the potential for the resolution of ambiguities involved in HSC bone marrow transplantation.
There is a change in the paradigm for HSC transplantation donor selection. Donor choice
favors haploidentical HCT than cord blood. This review provides a general overview of the current
events around hemopoietic stem cells, with emphasis on the rising trend of HSC transplantation, especially
haploidentical stem cell transplantation.
