Title:Mesenchymal Stem Cells Seeded Decellularized Tendon Scaffold for Tissue Engineering
Volume: 16
Issue: 2
Author(s): Niveditha K, Vineeth CA, Josna Joseph, Arun U, Annie John and Annie Abraham*
Affiliation:
- Department of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala 695581,India
Keywords:
Achilles tendon injuries, mesenchymal stem cells, decellularization, scaffolds, tissue engineering, potentials.
Abstract: Tendon is a collagenous tissue to connect bone and muscle. Healing of damaged/injured
tendon is the primary clinical challenge in musculoskeletal regeneration because they often react
poorly to treatment. Tissue engineering (a triad strategy of scaffolds, cells and growth factors) may
have the potential to improve the quality of tendon tissue healing under such impaired situations. Tendon
tissue engineering aims to synthesize graft alternatives to repair the injured tendon. Biological
scaffolds derived from decellularized tissue may be a better option as their biomechanical properties
are similar to the native tissue. This review is designed to provide background information on the current
challenges in curing torn/worn out the tendon and the clinical relevance of decellularized scaffolds
for such applications.
