Title:Prospective Function of Different Antioxidant Containing Natural Products in the Treatment of Neurodegenerative Diseases
Volume: 20
Issue: 8
Author(s): Mohammad Habibur Rahman, Rokeya Akter and Mohammad Amjad Kamal*
Affiliation:
- King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, P.O. Box 80216,Saudi Arabia
Keywords:
Anti-oxidant, natural product, Alzheimer's disease, neurodegeneration, biomarker, neurodegenerative diseases.
Abstract: Neurodegenerative diseases represent one of the most important public health problems
and concerns, as they are a growing cause of mortality and morbidity worldwide, particularly in the
elderly. However, natural products have a significant function in the avoidance of disease by boosting
health in humans as well as animals. These natural products have been scientifically acknowledged
to have a range of biological characteristics like antioxidant, and anti-inflammatory actions.
Both In vitro and in vivo studies have more recognized the convenience of natural products in different
preclinical models of neurodegenerative disorders. Moreover, most NPs comprise phytoconstituents,
including polyphenolic antioxidants; originate in herbs, fruits, nuts, vegetables, as well
as, also in marine with freshwater flora. These phytoconstituents might actively repress neuro-degeneration
and recover memory as like cognitive actions of the brain. Moreover, they are well recognized
to participate in an essential position in the prevention of like treatment of different neurodegenerative
diseases, like Alzheimer’s disease, Parkinson’s disease, epilepsy, and additional
neuronal disorders. However, the large-scale neuro-pharmacological actions of natural products
have been familiar owing to the consequence of also the inhibition of inflammatory processes, or
the up-regulation of various cell endurance proteins or a mixture of together. Owing to the shortage
of human studies on neuroprotective belongings of natural products, this review highlights a variety
of documented actions of natural products in vitro and in vivo preclinical models and their possible
neuro-protection applications by the accessible awareness in writing.
