Title:Current Status and Emerging Trend of Nanoshuttle in Biological Applications
Volume: 27
Issue: 1
Author(s): Pravin Shende*Pragya Sharma
Affiliation:
- Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’S NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai,India
Keywords:
Nanoshuttles, superparamagnetic, optical properties, nanomotor, Smart drug delivery, energy conversion.
Abstract: Nanoshuttles are unique structures that resemble double-headed arrows or a nanorod with sharp tips for
better penetration into the tumor cells, reduction of toxicity and minimization of off-targeting effect. These biologically-
inspired multimetallic or bimetallic nano swimmers are capable of transporting cargoes from one end to
another via self-propulsion in an efficient manner. Encapsulation with pH- and heat-sensitive polymers allows
nanoshuttles to release cargos at the targeted site in a controlled fashion. This review article focuses on the methods
of preparation and characterization of nanoshuttles with applications in the field of antineoplastic, antibacterial,
erectile dysfunction, electrochemical biosensing, anticounterfeiting, on-demand and targeted delivery system
for imaging as well as cell ablation therapy. Magnetic nanoshuttles exhibit modified optical properties for utilization
in diagnostic imaging for sensitive and early diagnosis of diseases. Smart drug delivery is achieved when
nanoshuttles are combined with nanomotors to exhibit distinctive, rapid and unidirectional movement in the
bloodstream. Cost-effective synthesis of nanoshuttles will extend their applications in the commercial sectors by
overcoming the limitations like scale-up and regulatory approval. In the near future, nanoshuttles will diversify in
the fields of energy conversion, energy storage, 3D printing, stem cell fabrication and theranostics.
