Title:Regulation of Breast Cancer Progression by Noncoding RNAs
Volume: 20
Issue: 10
关键词:
乳腺癌，微小RNA
摘要:
Background: Breast cancer (BC) is the cardinal cause of cancer-related deaths among
women across the globe. Our understanding of the molecular mechanisms underlying BC invasion
and metastasis remains insufficient. Recent studies provide compelling evidence on the prospective
contribution of noncoding RNAs (ncRNAs) and the association of different interactive mechanisms
between these ncRNAs with breast carcinogenesis. MicroRNAs (small ncRNAs) and lncRNAs (long
ncRNAs) have been explored extensively as classes of ncRNAs in the pathogenesis of several malignancies,
including BC.
Objective: In this review, we aim to provide a better understanding of the involvement of miRNAs
and lncRNAs and their underlying mechanisms in BC development and progression that may assist
the development of monitoring biomarkers and therapeutic strategies to effectively combat BC.
Conclusion: These ncRNAs play critical roles in cell growth, cell cycle regulation, epithelialmesenchymal
transition (EMT), invasion, migration, and apoptosis among others, and were observed
to be highly dysregulated in several cancers. The miRNAs and lncRNAs were observed to
interact with each other through several mechanisms that governed the expression of their respective
targets and could act either as tumor suppressors or as oncogenes, playing a crucial part in breast
carcinogenesis.
