Title:Paget’s Disease of Bone and Cardiovascular Risk: A Pilot Study
Volume: 19
Issue: 4
Author(s): Agostino Gaudio*, Luca Zanoli, Anastasia Xourafa, Rosario Rapisarda, Antonino Catalano, Salvatore Santo Signorelli and Pietro Castellino
Affiliation:
- Department of Clinical and Experimental Medicine, University of Catania, Catania,Italy
Keywords:
Paget's disease of bone, carotid intima-media thickness, pulse wave velocity, cardiovascular risk, disorder bone.
Abstract:
Background: The association between Paget’s disease of bone (PDB) and increased cardiovascular
(CV) risk has been suggested, but the literature is conflicting.
Objective: Our study aimed to evaluate two markers of CV risk, namely, common carotid artery intimamedia
thickness (cIMT) and the aortic pulse wave velocity (PWV) in patients with PDB.
Methods: We enrolled 12 patients with PDB and 58 control subjects, matched for age. The diagnosis of
PDB was based on clinical, radiological and biochemical parameters.
Results: Patients with PDB showed higher PWV values than the controls, whereas cIMT was slightly
but not significantly increased.
Conclusion: These findings, although limited by the small study population, represent an original observation
that deserves further study. The higher arterial stiffness in PDB could be related to the increased
bone turnover or the high levels of oxidative stress that characterize this population.
